フェニルカルバメート誘導体の製造方法

Japanese Patent JP2014510036

A

The invention relates to a process for preparing of phenyl carbamate derivatives useful in the treatment of CNS (central nervous system) disorders and representing compounds of formula (1): which process comprises carbamating, by reacting it with chlorosulfonyl isocyanate, a compound of formula (6): wherein X each independently is selected from halogens, n is an integer of 1-5, * denotes a chiral carbon atom, R 1 is linear or branched C 1-10 -alkyl, and the protecting group is one or more selected from trialkyl silyl groups and trialkylaryl silyl groups, wherein each alkyl group independently is linear, branched or cyclic C 1-4 -alkyl groups, and each aryl group independently is C 5-8 -aryl. Furthermore, the invention relates to certain intermediates useful in the above process and to methods for preparing them.

Choi, Young Moon

JP2013549358A

April 24, 2014

December 26, 2011

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Bio-Farm Solutions Company Limited

C07C269/02; C07C43/178; C07C49/245; C07C271/16; C07F7/08; C07B53/00; C07B61/00

US3265728A	1966-08-09
US3313700A	1967-04-11

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Hidekazu Miyoshi
Masakazu Ito
Yuko Hara

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