Title:
【発明の名称】マンガンキレート(▲II▼)NMRI造影剤
Document Type and Number:
Japanese Patent JP2773870
Kind Code:
B2
Abstract:
Manganese(II) chelates of N,N min -bis-(pyridoxal)alkylenediamine-N,N min -diacetic acids, N,N min -bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N min -diacetic acids, N,N min -bis-(pyridoxal)-1,2-arylenediamine-N,N min -diacetic acids, N,N min -bis-(pyridoxal)alkylenediamine-N-acetic acids, N,N min -bis-(pyridoxal)-1,2-cycloalkylenediamine-N-acetic acids, N,N min -bis-(pyridoxal)-1,2-arylenediamine-N-acetic acids, and their salts are highly stable, superior NMRI contrast agents. They maintain the manganese(II) ion in the +2 valence state. Preferred contrast agents are manganese(II) ion chelates of N,N min -bis-(pyridoxal)ethylenediamine- N,N min -diacetic acid, N,N min -bis-(pyridoxal)trans-1,2-cyclohexylenediamine-N,N min -diacetic acid, and the salts and esters thereof. Novel chelate forming compounds are the N,N min -bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N min -diacetic acids and N,N min -bis-(pyridoxal)-1,2-arylenediamine-N,N min -diacetic acids, N,N min -bis-(pyridoxal)alkylenediamine-N-acetic acids, N,N min -bis(pyridoxal)-1,2-cycloalkylenediamine-N-acetic acids, N,N min -bis-(pyridoxal)-1,2-arylenediamine-N-acetic acids, and their salts and esters.
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Inventors:
Scott M Rock Rage
Stephen Sea Key
Stephen Sea Key
Application Number:
JP10993088A
Publication Date:
July 09, 1998
Filing Date:
May 07, 1988
Export Citation:
Assignee:
Salter Incorporated
International Classes:
A61K49/06; C07D213/66; A61K49/00; C07D401/12; C07F13/00; (IPC1-7): C07F13/00; A61K49/00
Other References:
INORG.CHEM.=1984
INORG.CHEM.=1985
INT.J.NUCL.MED.BIOL.=1985
INORG.CHEM.=1985
INT.J.NUCL.MED.BIOL.=1985
Attorney, Agent or Firm:
Heiyoshi Odashima