Title:
生物還元による医薬的に活性なスルホキシドのエナンチオ選択的製造
Document Type and Number:
Japanese Patent JP3593132
Kind Code:
B2
Abstract:
PCT No. PCT/SE95/01416 Sec. 371 Date Dec. 18, 1995 Sec. 102(e) Date Dec. 18, 1995 PCT Filed Nov. 27, 1995A compound of formula (II), either as a single enantiomer or in an enantiomerically enriched form (II) wherein: and (wherein N in the benzimidazole moiety of Het2 means that one of the carbon atoms substituted by any one of R6 to R9 optionally may be exchanged for an unsubstituted nitrogen atom; R1, R2 and R3 are the same or different and selected from hydrogen, alkyl, alkoxy optionally substituted by fluorine, alkylthio, alkoxyalkoxy, dialkylamino, piperidino, morpholino, halogen, phenylalkyl, phenylakoxy; R4 and R4, are the same or different and selected from hydrogen, alkyl, aralkyl; R5 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy; R6 -R9 are the same or different and selected from hydrogen, alkyl, alkoxy, halogen, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, oxazolyl, trifluoroalkyl or adjacent groups R6 -R9 may complete together with the carbon atoms to which they are attached optionally substituted ring structures; R10 is hydrogen or alkoxycarbonyloxymethyl; R11 is hydrogen or forms an alkylene chain together with R3; R12 and R13 are the same or different and selected from hydrogen, halogen or alkyl) is obtained by stereoselective bioreduction of a compound of formula (II) in racemic form.
Inventors:
Graham, Daniel
Hoult, robert
Lindberg, Pell
Taylor, Stephen
Hoult, robert
Lindberg, Pell
Taylor, Stephen
Application Number:
JP51867096A
Publication Date:
November 24, 2004
Filing Date:
November 27, 1995
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
A61K31/44; A61K31/4427; A61P1/04; C07D401/12; C12P17/18; C12P41/00; C12R1/19; C12R1/37; (IPC1-7): C12P41/00; C07D401/12
Domestic Patent References:
| JP9504556A | ||||
| JP9504557A | ||||
| JP9504530A |
Foreign References:
| WO1994024867A1 | ||||
| WO1994025028A1 | ||||
| WO1992008716A1 |
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura