Title:
逆向き反復配列を含む組み換え遺伝子及びその利用
Document Type and Number:
Japanese Patent JP3765574
Kind Code:
B2
Abstract:
The object of the present invention is to improve a method for introducing dsRNA in such a way that RNAi effect is sustained in mammalian (mainly mouse) cells for a long period of time. The present invention provides a recombinant gene which contains inverted repeats of a target gene which can be expressed in mammalian cells.
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Inventors:
Motoya Katsuki
Ishida Mari
Minoru Kato
Ishida Mari
Minoru Kato
Application Number:
JP2002566344A
Publication Date:
April 12, 2006
Filing Date:
February 21, 2002
Export Citation:
Assignee:
Mitsubishi Chemical Corporation
International Classes:
C12N15/09; A01K67/027; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/11; C12N15/113
Domestic Patent References:
| JP2003526367A | ||||
| JP2003514533A | ||||
| JP2003529374A | ||||
| JP10191975A |
Foreign References:
| WO2000044914A1 |
Other References:
FEBS Lett.,Vol.479,No.3(2000)p.79-82
Nat.Cell Biol.,Vol.2,No.2(2000)p.70-75
Methods Enzymol.,Vol.302(1999)p.233-250
Nat.Genet.,Vol.24,No.2(2000.Feb.)p.180-183
Nat.Biotechnol.,Vol.18,No.8(2000.Aug.)p.896-898
Genes Dev.,Vol.15,No.2(2001.Jan.)p.188-200
Development,Vol.127,No.19(2000)p.4147-4156
Mol.Cell.Biol.,Vol.21,No.22(2001.Nov.)p.7807-7816
Biochem.Biophys.Res.Commun.,Vol.287,No.5(2001.Oct.)p.1099-1104
Proc.Natl.Acad.Sci.USA.,Vol.99,No.3(2002.Feb.5)p.1443-1448
Nature,Vol.411,No.6836(2001.May)p.494-498
Proc.Natl.Acad.Sci.USA.,Vol.98,No.17(2001.Aug.)p.9742-9747
Proc.Natl.Acad.Sci.USA.,Vol.98,No.25(2001.Dec.)p.14428-14433
Nat.Cell Biol.,Vol.2,No.2(2000)p.70-75
Methods Enzymol.,Vol.302(1999)p.233-250
Nat.Genet.,Vol.24,No.2(2000.Feb.)p.180-183
Nat.Biotechnol.,Vol.18,No.8(2000.Aug.)p.896-898
Genes Dev.,Vol.15,No.2(2001.Jan.)p.188-200
Development,Vol.127,No.19(2000)p.4147-4156
Mol.Cell.Biol.,Vol.21,No.22(2001.Nov.)p.7807-7816
Biochem.Biophys.Res.Commun.,Vol.287,No.5(2001.Oct.)p.1099-1104
Proc.Natl.Acad.Sci.USA.,Vol.99,No.3(2002.Feb.5)p.1443-1448
Nature,Vol.411,No.6836(2001.May)p.494-498
Proc.Natl.Acad.Sci.USA.,Vol.98,No.17(2001.Aug.)p.9742-9747
Proc.Natl.Acad.Sci.USA.,Vol.98,No.25(2001.Dec.)p.14428-14433
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
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