Title:
ナノ粒子インスリン製剤
Document Type and Number:
Japanese Patent JP4464129
Kind Code:
B2
Abstract:
Nanoparticulate insulin compositions having effective an average particle size of less than about 5 microns are described. The compositions exhibit retention of insulin bioactivity, increased bioavailability, and increased consistency of bioavailability as compared to prior macro-sized insulin compositions. Methods of making nanoparticulate insulin compositions, dosage forms containing them, and the use of such formulations in insulin therapy are also described.
More Like This:
Inventors:
Melisco-Reversage, Elaine
Oma Honey, Daniel
Wader hold, amy
Raof, Araz
McGurk, Simon, Elle.
Oma Honey, Daniel
Wader hold, amy
Raof, Araz
McGurk, Simon, Elle.
Application Number:
JP2003528522A
Publication Date:
May 19, 2010
Filing Date:
September 19, 2002
Export Citation:
Assignee:
Elan Pharma International, Limited
International Classes:
A61K9/08; A61K38/28; A61K9/12; A61K9/14; A61K9/19; A61K9/20; A61K9/48; A61K47/04; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/24; A61K47/26; A61K47/28; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61K47/44
Domestic Patent References:
| JP1163199A | ||||
| JP4504117A |
Foreign References:
| WO2000053164A1 | ||||
| WO2001026635A1 | ||||
| WO2000027363A1 | ||||
| WO1998051325A1 | ||||
| WO1999039700A1 | ||||
| WO2000051572A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki