Title:
内部で行なわれる生物検定の結果得られる反応混合物から光信号を生成し検出するための装置、及び、反応混合物内で行なわれる生物検定の結果得られる反応混合物の中味から光信号を生成し検出するための方法
Document Type and Number:
Japanese Patent JP4464130
Kind Code:
B2
Abstract:
Biochemical assays that are performed in cuvettes and in the wells of multi-well plates and that utilize excitation and light emission as labels for detection are enhanced by an illumination and detection system that supplies excitation light through an optical fiber that transmits excitation light from an excitation light source to the cuvette or well. Emission light produced by the excitation is then collected by a collimating lens and converted to a signal that is compiled by conventional software for analysis. The optical fiber and collimating lens can either be on the same side of the receptacle (generally the open side) or on opposite sides, i.e., one above and the other below. When the optical fiber and the collimating lens are both on the open side of the receptacle, they are arranged such that the direction of travel of the excitation light and the direction along which the emission light is collected are not coaxial, and preferably both are at an acute angle to the axis normal to the mouth of the receptacle. Illumination systems are also disclosed in which a ultraviolet, visible, or near-infrared light source is optically coupled to an optical fiber.
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Inventors:
Hillendal, James W.
Wald Bether, David E.
Naggy, Harry Earl.
Wald Bether, David E.
Naggy, Harry Earl.
Application Number:
JP2003531232A
Publication Date:
May 19, 2010
Filing Date:
September 24, 2002
Export Citation:
Assignee:
Bio - Rad Laboratories, Lee emissions Incorporated Rei tee de
International Classes:
G01N21/64; G01N21/25
Domestic Patent References:
| JP11051843A | ||||
| JP2001255272A | ||||
| JP2000329696A | ||||
| JP2001108684A | ||||
| JP2004500572A |
Foreign References:
| US6097025 | ||||
| WO2001069302A2 |
Attorney, Agent or Firm:
Atsushi Aoki
Jun Tsuruta
Tetsuro Shimada
Shimichi Akihisa
Masaya Nishiyama
Jun Tsuruta
Tetsuro Shimada
Shimichi Akihisa
Masaya Nishiyama