長時間放出特性を有する生分解性眼インプラント

Japanese Patent JP5128274

B2

The present invention provides a bioerodible implant for treating an ocular condition, the implant comprising (a) a dispersion comprising an active agent dispersed with a first bioerodible polymer, and (b) a particle comprising the active agent and a second bioerodible polymer, wherein the particle has an active agent release characteristic which differs from the active agent release characteristic of the dispersion (continued release period of 50d to 1y). In addition, the invention provides a bioerodible implant for treating a posterior ocular condition, the bioerodible implant comprising (a) a first region containing a first mixture of an active agent and a first bioerodible polymer, and (b) a second region containing a second mixture of the active agent and a second bioerodible polymer, wherein the first and second regions have different active agent release characteristics. Corresponding methods for producing bioerodible implants are also provided.

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WO/2005/120453	PHARMACEUTICAL COMPOSITIONS COMPRISING POLYETHYLENE GLYCOL HAVING A MOLECULAR WEIGHT OF LESS THAN 600 DALTONS

Thierry Niva Joli
Shear Jane Guo
Kin Lin

JP2007510790A

January 23, 2013

April 14, 2005

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ALLERGAN,INCORPORATED

A61K9/00; A61K31/56; A61K31/57; A61K31/573; A61K47/30; A61K47/34; A61P27/02; A61P37/08; A61K9/14; A61K9/20

JP2004535431A
JP2005517651A
JP2005532313A
JP2004501954A
JP11070138A
JP5017370A
JP2005511523A
JP1216917A
JP11501027A
JP64500034A

WO2002067993A1
WO2003000156A1
WO2003051328A1
WO2003094888A1
WO2003030941A1

Mitsuo Tanaka
Takuji Yamada
Kyousei Tamura
Yasuo Shibata
Kenichi Morizumi
Nagatoshi Shinagawa

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