骨髄性白血病の治療におけるエピジェネティック因子ならびにＣＤ３３およびＣＤ３を標的化する二重特異性化合物の組み合わせ

Title:

骨髄性白血病の治療におけるエピジェネティック因子ならびにＣＤ３３およびＣＤ３を標的化する二重特異性化合物の組み合わせ

Document Type and Number:

Japanese Patent JP6530409

Kind Code:

B2

Abstract:

The present invention provides a combination epigenetic factors and bispecific compounds targeting CD33 and CD3 in the treatment of myeloid leukemia, wherein the epigenetic factor is selected from the group consisting of histone deacetylase (HDAC) inhibitors, DNA methyltransferase (DNMT) I inhibitors, hydroxyurea, Granulocyte-Colony Stimulating Factor (G-CSF), histone demethylase inhibitors and ATRA (All Trans-retinoic acid). Accordingly, the invention provides a pharmaceutical composition comprising a CD33 targeting compound and at least one epigenetic factor and an epigenetic factor for use in the amelioration and/or treatment of a myeloid leukemia, wherein the epigenetic factor increases the responsiveness of a patient to a CD33 targeting compound. Moreover, the invention provides the use of at least one an epigenetic factor for increasing the responsiveness of a myeloid leukemia patient to a treatment with a CD33 targeting compound, a method for the treatment of a myeloid leukemia, the method comprising the administration of at least one epigenetic factor and a CD33 targeting compound to a patient in the need thereof and a kit comprising a pharmaceutical composition of the invention or an epigenetic factor of the invention and a bispecific CD33 targeting compound.

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Inventors:

Walter Roland Bee.
Subclave Marion
Krupka Christina

Application Number:

JP2016542329A

Publication Date:

June 12, 2019

Filing Date:

September 15, 2014

Export Citation:

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Assignee:

Amjien Incorporated

International Classes:

A61K39/395; A61K31/17; A61K31/4045; A61K31/7068; A61K38/19; A61P35/02; A61P43/00

Foreign References:

WO2012045752A1

Other References:

Leukemia,2012年12月14日,27,p.1107-1115
mAbs,2010年 7月 1日,2(4),p.440-448
Leukemia,2012年 7月20日,27,p.233-235

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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