ＲＯＲガンマモジュレータとしての新規化合物

Japanese Patent JP6661749

B2

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R¹, R², R³, R⁴, R⁵, R^a, R^b, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

WO/1999/010340	COMPOUNDS POSSESSING NEURONAL ACTIVITY
WO/1998/050346	ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS
JP2010195688	AMIDE AND UREA DERIVATIVE HAVING NPYY5 RECEPTOR ANTAGONISM

Sanjib Das
Laxmicant Atmaram Galat
Rajendra Luxman Halde
Sandeep Yadunath Scherke
Shiresh Ramesh Pardesh
Abraham Thomas
Nirima Kairatkar-Joshi
Daisy Manish Shah
Marini Basipie

JP2018505705A

March 11, 2020

August 02, 2016

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Glenmark Pharmaceuticals SA

C07D213/40; A61K31/415; A61K31/4418; A61K31/4965; A61K31/497; A61K31/506; A61K31/513; A61K31/5377; A61P1/04; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/06; A61P37/08; A61P43/00; C07D231/12; C07D239/36; C07D241/12; C07D241/18; C07D241/20; C07D401/04; C07D403/04; C07D407/12; C07D413/04; C07D413/12; C07D417/12

WO2013171729A2
WO2013029338A1
WO2014125426A1
WO2012158784A2

Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe

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