Title:
インビボまたはインビトロでの細胞が介在する結核の免疫学的診断の改善のための診断試薬
Document Type and Number:
Japanese Patent JP6698530
Kind Code:
B2
Abstract:
The present invention discloses in vitro and in vivo diagnostic methods with enhanced specificity and sensitivity for the detection of tuberculosis. The diagnostic reagents of the present invention can replace former mixtures/cocktails/pools of antigens comprising ESAT-6 but including ESAT6 improves the diagnosis even further.
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Inventors:
Claus, Claus
Hoff, slen, tetens
Rosenkrantz, Isa
Agel, els, marie
Andersen, Peter, Lavec
Hoff, slen, tetens
Rosenkrantz, Isa
Agel, els, marie
Andersen, Peter, Lavec
Application Number:
JP2016539075A
Publication Date:
May 27, 2020
Filing Date:
December 15, 2014
Export Citation:
Assignee:
Statens Salem Institute
International Classes:
G01N33/531; C07K16/12; C12N15/00; G01N33/569
Domestic Patent References:
| JP2012524733A | ||||
| JP2013539014A |
Foreign References:
| WO2012167307A1 | ||||
| WO2012011144A2 | ||||
| WO2012057904A1 |
Other References:
C. Casala et al.,Evaluation of two cocktails containing ESAT-6, CFP-10 and Rv-3615c in the intradermal test and the interferon-γ assay for diagnosis of bovine tuberculosis,Preventive Veterinary Medicine,2012年,Vol.105,pp.149-154
Kerry A. Millingtona et al.,Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection,PNAS,2011年,Vol.108, No.14,pp.5730-5735
Kerry A. Millingtona et al.,Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection,PNAS,2011年,Vol.108, No.14,pp.5730-5735
Attorney, Agent or Firm:
Patent business corporation Kita Aoyama International