Title:
光学活性５−ヒドロキシ−３−ケトエステル類の製造方法
Document Type and Number:
Japanese Patent JP6795794
Kind Code:
B2
Abstract:
The object of the present invention is to provide a method for producing in high yield with high stereoselectivity an optically active 5-hydroxy-3-ketoester compound which is useful as an intermediate for a pharmaceutical. A novel method for producing an optically active 5-hydroxy-3-ketoester compound in which an asymmetric aldol reaction by use of 1,3-diene compound is carried out in the presence of an optically active binaphthol-titanium complex together with a substituted nitrogen-containing 5 or 6-membered aromatic heterocyclic compound to obtain an optically active 5-hydroxy-3-ketoester compound in high yield with high stereoselectivity; and a novel production intermediate having a crystalline form.
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Inventors:
Tateyama Shoichi
Shinya Naito
Yasutaka Takada
Ishida Mariko
Hirohide Tachibanayama
Shinya Naito
Yasutaka Takada
Ishida Mariko
Hirohide Tachibanayama
Application Number:
JP2019074335A
Publication Date:
December 02, 2020
Filing Date:
April 09, 2019
Export Citation:
Assignee:
Nissan Chemical Co., Ltd.
International Classes:
C07D239/42
Domestic Patent References:
| JP2009500388A | ||||
| JP2010511029A |
Foreign References:
| WO2003042180A1 | ||||
| WO2006106526A1 | ||||
| WO2008096257A1 | ||||
| WO2006100689A1 | ||||
| WO2011021058A1 | ||||
| WO2011121598A1 | ||||
| WO2009128091A1 |
Attorney, Agent or Firm:
Hanabusa Patent and Trademark Office