Title:
【発明の名称】ドーパミンD4リガンドとしてのキノロン誘導体
Document Type and Number:
Japanese Patent JPH08508466
Kind Code:
A
Abstract:
PCT No. PCT/GB94/00383 Sec. 371 Date Aug. 30, 1995 Sec. 102(e) Date Aug. 30, 1995 PCT Filed Feb. 25, 1994 PCT Pub. No. WO94/20471 PCT Pub. Date Sep. 15, 1994A class of chemical compounds comprising a 2(1H)-quinolone moiety and a substituted heterocyclic moiety, linked via the 3-position of the 2(1H)-quinolone moiety by a methylene group, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs.
Inventors:
Kragowski, Gionas Jozef
Leeson, Paul David
Mower, Ian Michael
Leeson, Paul David
Mower, Ian Michael
Application Number:
JP51969794A
Publication Date:
September 10, 1996
Filing Date:
February 25, 1994
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
A61K31/44; A61K31/4427; A61K31/47; A61K31/495; A61P25/02; A61P25/18; A61P25/20; C07D215/227; C07D401/06; C07D215/22; (IPC1-7): C07D401/06; A61K31/44; A61K31/495; C07D401/06
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)