Title:
【発明の名称】ヒトG-タンパク質受容体HCEGH45
Document Type and Number:
Japanese Patent JPH11506921
Kind Code:
A
Abstract:
A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
Inventors:
Soppet, Daniel Earl
Lee
Rosen, Craig A.
Ruben, Stephen M
Lee
Rosen, Craig A.
Ruben, Stephen M
Application Number:
JP50037097A
Publication Date:
June 22, 1999
Filing Date:
June 06, 1995
Export Citation:
Assignee:
HUMAN GENOME SCIENCES, INC.
International Classes:
G01N33/53; A61K38/00; A61K45/00; A61K48/00; A61P1/04; A61P3/02; A61P7/02; A61P9/02; A61P9/08; A61P9/10; A61P9/12; A61P13/02; A61P15/00; A61P25/00; A61P25/04; A61P25/18; A61P25/24; A61P25/26; A61P37/08; A61P43/00; C07K14/705; C07K14/715; C07K16/28; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; G01N33/15; C12R1/91; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61K48/00; C07K14/705; C07K16/28; C12N5/10; C12P21/02; C12Q1/68; G01N33/15; G01N33/53
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)