Title:
免疫刺激オリゴヌクレオチド複合体
Document Type and Number:
Japanese Patent JPWO2017007027
Kind Code:
A1
Abstract:
ホスホロチオエート化されていなくてもI型IFN誘導活性に優れ、且つ、工業的生産に適する、免疫刺激オリゴヌクレオチドを提供する。１０〜１００塩基対を含む線状の２本鎖オリゴヌクレオチドであって、該２本鎖を構成する各１本鎖オリゴヌクレオチドは、ホスホジエステルを介したシトシン-グアニン配列（CpG）を２〜２０個含み、各１本鎖オリゴヌクレオチドのヌクレオチド間の結合の９０％以上がホスホジエステル結合である、２本鎖オリゴヌクレオチド。
Inventors:
Nobutaka Hanakata
Hiroshi Otsuka
Takafumi Harada
Hiroshi Otsuka
Takafumi Harada
Application Number:
JP2017527515A
Publication Date:
April 19, 2018
Filing Date:
July 08, 2016
Export Citation:
Assignee:
National Institute for Materials Science
Denka Co., Ltd.
Denka Co., Ltd.
International Classes:
C12N15/117; A61K31/713; A61K39/00; A61K39/35; A61K39/39; A61P31/00; A61P35/00; A61P37/04; A61P37/08
Domestic Patent References:
| JP2007506790A | 2007-03-22 | |||
| JP2012200233A | 2012-10-22 | |||
| JP2009528027A | 2009-08-06 | |||
| JP2007500018A | 2007-01-11 |
Foreign References:
| US20040198688A1 | 2004-10-07 | |||
| US8304396B2 | 2012-11-06 |
Other References:
NANO BIOMEDICINE, vol. 5, no. 2, JPN6020019024, 2013, pages 55 - 63, ISSN: 0004282894
BMC BIOTECHNOLOGY, vol. 11, JPN6020019025, 2011, pages 88, ISSN: 0004282895
VETERINARY IMMUNOLOGY AND IMMNOPATHOLOGY, vol. Vol.101, No.1-2, JPN6020019026, 2004, pages 87 - 102, ISSN: 0004282896
BIOMATERIALS, vol. 30, JPN6020019027, 2009, pages 5701 - 5706, ISSN: 0004282897
BMC BIOTECHNOLOGY, vol. 11, JPN6020019025, 2011, pages 88, ISSN: 0004282895
VETERINARY IMMUNOLOGY AND IMMNOPATHOLOGY, vol. Vol.101, No.1-2, JPN6020019026, 2004, pages 87 - 102, ISSN: 0004282896
BIOMATERIALS, vol. 30, JPN6020019027, 2009, pages 5701 - 5706, ISSN: 0004282897
Attorney, Agent or Firm:
Asamura patent office