2,4-PYRIMIDINEDIAMINE USEFUL IN TREATMENT OF NEOPLASTIC DISEASE, INFLAMMATORY AND IMMUNE SYSTEM DISORDER

Japanese Patent JP2010241830

A

To provide new pyrimidine derivatives, some types of the new pyrimidine derivatives, their production method, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

The pyrimidine derivatives are expressed by formula I [wherein R is selected from 6-10C aryl, 5-10C heteroaryl, 3-12C cycloalkyl and 3-10C heterocycloalkyl; and R0-R6 are as defined specifically]. The compounds of formula I are used for production of pharmaceuticals for treating diseases responding to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.

JPH08502981	INDUSTRIAL APPLICABILITY A method for treating hypertension and a composition of (+) doxazosin.
JP2023527379	Substituted benzamides as modulators of TREX1
WO/1992/008698	RETROVIRAL PROTEASE INHIBITORS

GARCIA-ECHEVERRIA CARLOS
KANAZAWA TAKAKI
KAWAHARA EIJI
MASUYA KEIICHI
MATSUURA NAOKO
MIYAKE TAKAHIRO
OMORI OSAMU
UMEMURA ICHIRO
STEENSMA RUO
CHOPIUK GREG
JIANG JIQING
WAN YONGQIN
QUIAN DING
ZHANG QIONG
GRAY NATHANAEL SCHIANDER
KARANEWSKY DONALD

JP2010162177A

October 28, 2010

July 16, 2010

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NOVARTIS AG
IRM LLC

A61K31/505; A61K31/438; A61K31/506; A61K31/5377; A61K31/5383; A61K31/541; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P35/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D239/48; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D405/14; C07D498/04; C07D239/50; C07D403/14; C07D417/12; C07D491/113

JP4607879B2

2011-01-05

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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