USE OF S1P RECEPTOR AGONIST IN CARDIOPATHY

Title:

USE OF S1P RECEPTOR AGONIST IN CARDIOPATHY

Document Type and Number:

Japanese Patent JP2010241829

Kind Code:

A

Abstract:

To provide a new use of a sphingosine-1-phosphate (S1P) receptor agonist in the treatment of chronic cardiac insufficiency, congestive heart failure, arrhythmic or tachyarrhythmia.

The invention provides the use of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a FTY720 phosphate in a free form or in the form of a pharmaceutically acceptable salt, as S1P receptor agonists.

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Inventors:

BRINKMANN VOLKER
FEUTREN GILLES
HOF ROBERT PAUL

Application Number:

JP2010162170A

Publication Date:

October 28, 2010

Filing Date:

July 16, 2010

Export Citation:

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Assignee:

NOVARTIS AG

International Classes:

A61K31/137; C07D333/56; A61K31/13; A61K31/381; A61K31/661; A61K38/22; A61K38/55; A61K45/00; A61K45/06; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P43/00

Other References:

JPN6009049532; Ｋａｒｏｌｙ　ＬＩＬＩＯＭ: 'Ｓｐｈｉｎｇｏｓｙｌｐｈｏｓｐｈｏｃｈｏｌｉｎｅ　ｉｓ　ｎａｔｕｒａｌｌｙ　ｏｃｃｕｒｒｉｎｇ　ｌｉｐｉｄ　ｍｅｄｉａｔｏｒ　ｉｎ　ｂｌｏｏｄ　ｐｌａｓｍａ：ａ　ｐｏｓｓｉｂｌｅ　ｒｏｌｅ　ｉｎ　ｒｅ' ＢＩＯＣＨＥＭＩＣＡＬ　ＪＯＵＲＮＡＬＶｏｌ．　３５５，　Ｎｏ．　１, 2001, Ｐａｇｅｓ　１８９-１９７
JPN6012064823; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙｖｏｌ．２７７，　ｎｏ．２４, 2002, ｐ．２１４５３-２１４５７

Attorney, Agent or Firm:

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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