ANTIBODIES AGAINST HUMAN IL-12

Title:

ANTIBODIES AGAINST HUMAN IL-12

Document Type and Number:

Japanese Patent JP2013139458

Kind Code:

A

Abstract:

To provide human IL-12 antibodies that has a higher potency and greater efficacy in neutralizing human IL-12 bioactivity than known heterodimer specific IL-12 monoclonal antibodies.

The heterodimer specific antibodies recognize one or more epitopes of the human IL-12 p75 heterodimer, but do not bind to the p40 subunit alone. The heterodimer specific IL-12 antibodies neutralize rhesus monkey IL-12 bioactivity with a potency similar to their potency for neutralizing human IL-12 bioactivity, thereby making them useful IL-12 antagonists.

Inventors:

GATELY MAURCIE KENT
PRESKY DAVID HOWARD

Application Number:

JP2013029936A

Publication Date:

July 18, 2013

Filing Date:

February 19, 2013

Export Citation:

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Assignee:

HOFFMANN LA ROCHE

International Classes:

C07K16/24; A61K39/395; A61P1/04; A61P3/10; A61P19/02; A61P25/00; A61P29/00; A61P37/02; A61P37/06; C07K16/46; C12N5/10; C12N5/20; C12P21/08; C12N15/09

Domestic Patent References:

JPH09510444A	1997-10-21
JPH0753594A	1995-02-28
JPH0856692A	1996-03-05

Foreign References:

WO1995024918A1	1995-09-21
WO1997015327A1	1997-05-01

Other References:

JPN5001008323; ＺＯＵ，　Ｊ．Ｊ．　ｅｔ　ａｌ．: ＪＯＵＲＮＡＬ　ＯＦ　ＢＩＯＬＯＧＩＣＡＬ　ＣＨＥＭＩＳＴＲＹＶｏｌ．２７０，　Ｎｏ．１１, 19951101, Ｐ．５８６４-５８７１
JPN5001008321; ＣＡＲＴＥＲ，　Ｒ．Ｗ．　ｅｔ　ａｌ．: ＨＹＢＲＩＤＯＭＡＶｏｌ．１６，　Ｎｏ．４, 19970401, Ｐ．３６３-３６９
JPN5001008323; ＺＯＵ，　Ｊ．Ｊ．　ｅｔ　ａｌ．: ＪＯＵＲＮＡＬ　ＯＦ　ＢＩＯＬＯＧＩＣＡＬ　ＣＨＥＭＩＳＴＲＹＶｏｌ．２７０，　Ｎｏ．１１, 19951101, Ｐ．５８６４-５８７１
JPN5001008321; ＣＡＲＴＥＲ，　Ｒ．Ｗ．　ｅｔ　ａｌ．: ＨＹＢＲＩＤＯＭＡＶｏｌ．１６，　Ｎｏ．４, 19970401, Ｐ．３６３-３６９

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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