アリール−フェニル−スルホンアミド−シクロアルキル化合物とその使用

Title:

アリール−フェニル−スルホンアミド−シクロアルキル化合物とその使用

Document Type and Number:

Japanese Patent JP5771524

Kind Code:

B2

Abstract:

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as "APSAC compounds"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc. Formula (I).

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Inventors:

Craig, Ian Robert
Sheridan, Rose Mary
Fisher, Raymond
Tozer, Matthew, John
Classe, Juha, Andrew
Smith, Andrew
Toughnel, Andrew, Robert
Wandhof, Robert, Jürgen

Application Number:

JP2011527394A

Publication Date:

September 02, 2015

Filing Date:

September 18, 2009

Export Citation:

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Assignee:

Pimco 2664 Limited

International Classes:

C07C311/20; A61K31/18; A61K31/40; A61K31/4418; A61P1/04; A61P9/10; A61P11/00; A61P17/06; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; C07C311/29; C07D213/61

Domestic Patent References:

JP2009542673A
JP2007530546A
JP2005504126A
JP2008501670A

Other References:

I. R. GREIG et al.,DEVELOPMENT AND CHARACTERIZATION OF BIPHENYLSULFONAMIDES AS NOVEL INHIBITORS OF BONE RESORPTION,JOURNAL OF MEDICINAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY,2006年,49(25),7487-7492

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka

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