Title:
1,1,1-トリフルオロアセトンの不斉水素化
Document Type and Number:
Japanese Patent JP5345932
Kind Code:
B2
Abstract:
The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex catalyst represented by formula Ru(E)(E')(L)(A) wherein E, E' are both chloro or E is hydrogen and E' is BH4; L is a chiral diphosphine ligand; and A is an optionally chiral diamine wherein hydrogenation occurs in the presence of a weak base, with or without an additive, when E and E' are both chloro or b) in the absence of a base and an additive when E and E' are hydrogen and BH4.
Inventors:
Puenter, Kurt
Waldmeier, Pius
Waldmeier, Pius
Application Number:
JP2009521220A
Publication Date:
November 20, 2013
Filing Date:
July 17, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07C29/145; C07C31/38; C07B53/00; C07B61/00
Domestic Patent References:
| JP2003104993A | ||||
| JP2002080429A | ||||
| JP2003252884A | ||||
| JP2002284790A |
Foreign References:
| WO2005016943A1 |
Other References:
M.BUCCIARELLI,SYNTHESIS,1983年11月,P897-899
TANG W,CHEMICAL REVIEWS,米国,ACS,2003年,V103 N8,P3029-3069
TANG W,CHEMICAL REVIEWS,米国,ACS,2003年,V103 N8,P3029-3069
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata