NEW MATERIAL:An azacycloalkane compound expressed by formula I (R is alkyl; Y is alkyl, alkoxy, acyloxy, alkylthio, hydroxyl group, carboxyl or 1W12C alkoxycarbonyl; A is -O-, -S- or -NH-; m is 2W7; n is 1W15).
EXAMPLE: 5-Methyl-1-(4-Heptylthiobutyl)azacyclopentan-2-one.
USE: Useful as an absorption promoter, having remarkable enhancing action on penetrability and permeability of chemicals as well as extremely weak local irritation to biomembranes, systemic toxicity, etc., exhibiting high safety, individually showing antimicrobial action and utilizable as a drug for promoting drug transmission in not only medicines but also cosmetics which are quasi-drugs, agricultural chemicals, insecticides, etc.
PREPARATION: For example, as shown in the reaction formulas, a dihalogenoalkyl is added to a reaction product of a substituted azacyloalkan-2- one with a catalyst and the resultant product is reacted with a thiol in the presence of a dehalogenating agent to afford the aimed compound expresses by formula Il.
INOUE TOSHITAKA
YATANI TERUMI
NAKAJIMA MIKIO
SAIDA MASARU
SHIMOZONO YUJI
SAKAI MICHIYORI
| JPS5398816A | 1978-08-29 |
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