Title:
P2X7受容体アンタゴニストとしてのベンズアミドおよびヘテロアリールアミド
Document Type and Number:
Japanese Patent JP4365218
Kind Code:
B2
Abstract:
The present invention relates to novel to P2X7 inhibitors of formula I and to processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, and their use in therapy. The active compounds of the present invention are potent inhibitors of P2X7 and as such are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
Inventors:
Allen Jacob Da Planter
Chakra Pani Sabla Manium
Chakra Pani Sabla Manium
Application Number:
JP2003544027A
Publication Date:
November 18, 2009
Filing Date:
November 04, 2002
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D211/76; A61K31/4196; A61K31/421; A61K31/451; A61K31/495; A61K31/53; A61K31/5415; A61P1/02; A61P1/04; A61P3/10; A61P7/00; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P21/04; A61P25/00; A61P25/02; A61P25/06; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P33/06; A61P35/00; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07D211/40; C07D211/42; C07D213/64; C07D213/69; C07D241/08; C07D249/12; C07D253/06; C07D253/075; C07D263/22; C07D263/24; C07D279/16; C07D295/14; C07D405/12; C07D407/12; C07D409/12; A61K31/4418
Domestic Patent References:
| JP5163274A | ||||
| JP8053449A | ||||
| JP2501388A | ||||
| JP56128757A | ||||
| JP57112371A | ||||
| JP61500069A | ||||
| JP3163060A | ||||
| JP9509923A | ||||
| JP5186436A | ||||
| JP9040673A | ||||
| JP4356463A | ||||
| JP3106865A | ||||
| JP53139534A |
Other References:
Bull. Korean Chem. Soc.,1993年,Vol.14, No.6,pp.717-722
Attorney, Agent or Firm:
High Hoji Koji
Junko Miyazawa
Noh four
Yoshinobu Murofushi
Junko Miyazawa
Noh four
Yoshinobu Murofushi