ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用

Japanese Patent JP5538239

B2

The present invention relates to compounds defined by formula (I) wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.

JPH085865	[Title of Invention] A novel aconitine compound and an analgesic / anti-inflammatory agent containing them as an active ingredient.
WO/2012/125871	ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF
JP5340729	Therapeutic agent

Echult, Matthias
Himmelsbach, Frank
Hamilton, Bradford
Peters, Stephan

JP2010546254A

July 02, 2014

February 10, 2009

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Boehringer Ingelheim International GmbH

C07D221/22; A61K31/437; A61K31/438; A61K31/439; A61K31/4545; A61K31/46; A61K31/4709; A61K31/4725; A61K31/496; A61K31/4985; A61K31/5377; A61K31/538; A61K31/55; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P19/10; A61P25/22; A61P25/24; A61P25/28; A61P27/06; A61P37/02; A61P43/00; C07D401/06; C07D401/14; C07D413/06; C07D451/04; C07D451/14; C07D471/04; C07D471/10; C07D471/18; C07D487/04; C07D495/04

US3539637
US3341538
GB1077711A
WO2008000951A1
WO2006024628A1
WO2007051810A1
WO2006040329A1
WO2009063061A1

Hajime Tsukuni
Fusayuki Saito

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