Title:
アミノリン脂質に結合する治療結合体を用いる癌処置方法
Document Type and Number:
Japanese Patent JP5721693
Kind Code:
B2
Abstract:
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.
Inventors:
Philip E. Soap
Sophia Run
Rolf A. Brecken
Sophia Run
Rolf A. Brecken
Application Number:
JP2012262623A
Publication Date:
May 20, 2015
Filing Date:
November 30, 2012
Export Citation:
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
A61K39/395; A61K9/127; A61K38/43; A61K45/00; A61K47/48; A61K49/00; A61K49/04; A61K51/00; A61K51/10; A61P9/00; A61P35/00; C07K16/28; C12P21/08
Other References:
FISHMAN, P,Int J oncol,1997年,Vol.10,p.901-904
BALDWIN,R.W. et al,Monoclonal antibody immunoconjugates for cancer treatment,Curr Opin Immunol,1989年,Vol.1, No.5,p.891-4
インナービジョン,1992年,Vol.7, No.7,p.25-26
KOOPMAN,G. et al,Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apopt,Blood,1994年,Vol.84, No.5,p.1415-20
BALDWIN,R.W. et al,Monoclonal antibody immunoconjugates for cancer treatment,Curr Opin Immunol,1989年,Vol.1, No.5,p.891-4
インナービジョン,1992年,Vol.7, No.7,p.25-26
KOOPMAN,G. et al,Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apopt,Blood,1994年,Vol.84, No.5,p.1415-20
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita