Title:
免疫応答のアジュバントとしてのケモカイン
Document Type and Number:
Japanese Patent JP2004520043
Kind Code:
A
Abstract:
Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating or inhibiting the migration or activation of antigen-presenting dendritic cells. In particular, chemokines are used to initiate, amplify or modulate an immune response. In one embodiment, chemokines are used to attract dentritic cells to the site of antigen delivery. An increase number of dendritic at the site of antigen delivery means more antigen uptake and a modified immune response.
Inventors:
Vicari, Allen Py.
Kou, Christoph
La face, julake
Kou, Christoph
La face, julake
Application Number:
JP2002559057A
Publication Date:
July 08, 2004
Filing Date:
January 22, 2002
Export Citation:
Assignee:
Schering Corporation
International Classes:
C12N15/09; A61K38/00; A61K38/19; A61K38/20; A61K39/00; A61K39/39; A61K45/00; A61K48/00; A61P1/00; A61P1/16; A61P1/18; A61P11/00; A61P13/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P25/00; A61P27/02; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K14/005; C07K14/195; C07K14/37; C07K14/47; C07K14/82; C07K19/00; (IPC1-7): C12N15/09; A61K38/00; A61K39/00; A61K45/00; A61K48/00; A61P1/00; A61P1/16; A61P1/18; A61P11/00; A61P13/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P25/00; A61P27/02; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K14/005; C07K14/195; C07K14/37; C07K14/47; C07K14/82; C07K19/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita