Title:
キラルスピロ−ピリジルアミドフォスフィン配位子化合物、その合成方法及びその利用
Document Type and Number:
Japanese Patent JP5923105
Kind Code:
B2
Abstract:
The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7'-amino-1,1'-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7'-amino-1,1'-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol%, and the enantioselectivity of the reaction is up to 99.9%ee.
Inventors:
Zhou Lin
Xie Jian Flower
Liu Akatsuki Gloss
Xie sword wave
Royal new
Xie Jian Flower
Liu Akatsuki Gloss
Xie sword wave
Royal new
Application Number:
JP2013539127A
Publication Date:
May 24, 2016
Filing Date:
November 18, 2011
Export Citation:
Assignee:
Jejan Jiuzhou Pharma Science and Technology Company Limited
International Classes:
C07F9/58; B01J31/24; C07B41/02; C07B53/00; C07C29/145; C07C31/135; C07C33/22; C07C33/26; C07C33/30; C07C33/46; C07C35/24; C07C35/27; C07C41/26; C07C43/23; C07C67/31; C07C69/675; C07C69/712; C07C69/732; C07C69/78; C07F15/00
Foreign References:
| CN101671365A | ||||
| WO2001000581A1 | ||||
| WO2009129700A1 | ||||
| CN1439643A |
Other References:
Jian-Bo Xie et al.,Journal of the American Chemical Society,2010年,Vol.132,p.4538-4539
Attorney, Agent or Firm:
Keisei Nishikawa
Mizuhiji Katsuhisa
Yoshishige Takeo
Takeshi Sakaguchi
Hidetoshi Kitade
Nakaishi Haruki
Kyohei Tokioka
Yutaka Kimura
Mizuhiji Katsuhisa
Yoshishige Takeo
Takeshi Sakaguchi
Hidetoshi Kitade
Nakaishi Haruki
Kyohei Tokioka
Yutaka Kimura