COMBINATION THERAPY

Japanese Patent JP2002275096

A

To provide a method for reducing a tissue damage caused by ischemia, and to provide a kid used for the method.

This method for reducing the tissue damage caused by ischemia comprises administering a medicinal composition containing an NHE-1 inhibitor, and a proper amount of a second compound selected from the group consisting of (a) a complement modulator, (b) a metabolic modulator, (c) an anti-apoptosis agent, (d) a nitrogen monoxide synthase-related agent, and (e) an enzyme/protein modulator [selected from the group consisting of a protein kinase C activator, an endothelin-converting enzyme inhibitor, a tissue-activating fibrinolysis inhibitor(TAF1), an Na-/Ca+2 exchanger isoform-1 (NCX-1) inhibitor, and a poly(ADP ribose)synthetase(PARS/PARP) inhibitor]. The kid comprises the medicinal composition and a container. The NHE-1 inhibitor includes a compound of formula (1) (a five-membered, diaza or diunsaturated ring having bound carbon, and the adjacent nitrogen, or the like is included) and its prodrug.

TRACEY WAYNE ROSS
HILL ROGER J

JP2002012315A

September 25, 2002

January 22, 2002

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PFIZER PROD INC

A61K31/155; A61K31/166; A61K31/18; A61K31/19; A61K31/192; A61K31/198; A61K31/336; A61K31/404; A61K31/415; A61K31/4155; A61K31/416; A61K31/4184; A61K31/4192; A61K31/4709; A61K31/4725; A61K31/4745; A61K45/06; A61P9/00; A61P9/04; A61P9/10; A61P41/00; A61P43/00; (IPC1-7): A61K45/06; A61K31/155; A61K31/166; A61K31/18; A61K31/19; A61K31/192; A61K31/198; A61K31/336; A61K31/404; A61K31/415; A61K31/4155; A61K31/416; A61K31/4184; A61K31/4192; A61K31/4709; A61K31/4725; A61P9/00; A61P9/04; A61P41/00; A61P43/00

Kazuo Shamoto (5 outside)

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