Title:
トロンビン処理幹細胞に由来するエクソソームを含む皮膚傷治療用組成物
Document Type and Number:
Japanese Patent JP6826135
Kind Code:
B2
Abstract:
The present disclosure relates to a pharmaceutical composition comprising an exosome derived from a thrombin-treated stem cell as an effective ingredient for preventing or treating a skin wound, a pharmaceutical formulation containing the same, and a production method thereof. Being a cell-free agent, an exosome-based therapeutic agent of the present disclosure has a low risk of carcinogenesis and no problems of graft rejection as well as being little liable to occur microvascular obstruction. The agent, which is not a cell, but a material isolated from a cell, can be subjected to medication development into an off-the-shelf product which allows for the reduction of production cost. The agent has the advantage of exhibiting outstanding angiogenesis and skin wound treatment effects even at a low concentration of exosomes thanks to the thrombin treatment effect.
Inventors:
Chan, Yun Sil
Park, Won Sung
Song, Dong Kyun
Anne, So Yoon
Park, Won Sung
Song, Dong Kyun
Anne, So Yoon
Application Number:
JP2018568285A
Publication Date:
February 03, 2021
Filing Date:
June 27, 2017
Export Citation:
Assignee:
Samsung Life Public Welfare Foundation
International Classes:
A61K35/28; A61K9/06; A61K9/08; A61K9/107; A61K9/12; A61K9/70; A61K35/30; A61K35/34; A61K35/35; A61K35/36; A61K35/50; A61K35/51; A61K38/18; A61K38/19; A61K48/00; A61P17/02; A61P43/00
Foreign References:
| WO2015088288A1 |
Other References:
Stem Cells,2015年,Vol.33,pp.2158-2168
皮膚,1996年,Vol.38, No.1,pp.132-147
Inflammation and Regeneration,2004年,Vol.24, No.6,pp.656-660
東医大誌,2002年,Vol.60, No.6,pp.441-447
皮膚,1996年,Vol.38, No.1,pp.132-147
Inflammation and Regeneration,2004年,Vol.24, No.6,pp.656-660
東医大誌,2002年,Vol.60, No.6,pp.441-447
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Kato Kazunori