Title:
CRYSTALLINE POLYMORPH OF MUSCARINIC ACETYLCHOLINE RECEPTOR AGONIST
Document Type and Number:
Japanese Patent JP2022119840
Kind Code:
A
Abstract:
To provide novel crystalline forms of a spiro-compound which acts as a muscarinic acetylcholine receptor agonist.SOLUTION: The present invention relates to a crystalline polymorph of monohydrate Form III of the following compound having an X-ray powder diffraction pattern containing at least one of the following 2-theta values (±0.2): 12.3, 17.3, 17.5, 19.9, 21.6, 24.6, 26.3, and 35.4, as measured using CuKα radiation, and substantially free of peaks having 2 theta values in the range of 10.8-11.9.SELECTED DRAWING: None
More Like This:
Inventors:
ABRAHAM FISHER
NIRA BAR-NER
MANFRED WINDISCH
NIRA BAR-NER
MANFRED WINDISCH
Application Number:
JP2022081233A
Publication Date:
August 17, 2022
Filing Date:
May 18, 2022
Export Citation:
Assignee:
NSC THERAPEUTICS GMBH
International Classes:
C07D513/10; A61K9/20; A61K9/48; A61K31/438; A61K45/00; A61K47/04; A61K47/12; A61K47/36; A61K47/38; A61K47/42; A61P1/14; A61P3/04; A61P15/02; A61P17/16; A61P19/02; A61P25/00; A61P25/02; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/28; A61P25/30; A61P25/32; A61P27/04; A61P27/06; A61P27/10; A61P29/00; A61P37/02; A61P43/00
Domestic Patent References:
| JP2005530742A | 2005-10-13 | |||
| JP7163280B2 | 2022-10-31 | |||
| JPH09503491A | 1997-04-08 |
Other References:
PHARM TECH JAPAN, vol. 18, no. 10, JPN7014002019, 2002, pages 81 - 96, ISSN: 0005114411
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, JPN6009053755, 15 January 2007 (2007-01-15), ISSN: 0005114412
PHARM STAGE, JPN6011001457, 2007, ISSN: 0005114413
STEPHEN BYRN: "PHARMACEUTICAL SOLIDS: A STRATEGIC APPROACH TO REGULATORY CONSIDERATIONS", PHARMACEUTICAL RESEARCH, vol. VOL:12, NR:7, JPN5020000127, July 1995 (1995-07-01), pages 945 - 954, XP055307460, ISSN: 0005114414, DOI: 10.1023/A:1016241927429
BRITTAIN H G: "SPECTRAL METHODS FOR THE CHARACTERIZATION OF POLYMORPHS AND SOLVATES", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. VOL:86, NR:4, JPN5020000128, April 1997 (1997-04-01), pages 405 - 412, ISSN: 0005114415
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, JPN6009053755, 15 January 2007 (2007-01-15), ISSN: 0005114412
PHARM STAGE, JPN6011001457, 2007, ISSN: 0005114413
STEPHEN BYRN: "PHARMACEUTICAL SOLIDS: A STRATEGIC APPROACH TO REGULATORY CONSIDERATIONS", PHARMACEUTICAL RESEARCH, vol. VOL:12, NR:7, JPN5020000127, July 1995 (1995-07-01), pages 945 - 954, XP055307460, ISSN: 0005114414, DOI: 10.1023/A:1016241927429
BRITTAIN H G: "SPECTRAL METHODS FOR THE CHARACTERIZATION OF POLYMORPHS AND SOLVATES", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. VOL:86, NR:4, JPN5020000128, April 1997 (1997-04-01), pages 405 - 412, ISSN: 0005114415
Attorney, Agent or Firm:
Shinsuke Umeda
Yuko Matsutoya
Yu Morita
Chisuke Konno
Nobuto Oki
Yuko Matsutoya
Yu Morita
Chisuke Konno
Nobuto Oki
Previous Patent: Energy Absorber and Method of Absorbing Energy
Next Patent: Dental mill blank and manufacturing method thereof
Next Patent: Dental mill blank and manufacturing method thereof