18β-グリチルレチン酸の誘導体

Title:

18β-グリチルレチン酸の誘導体

Document Type and Number:

Japanese Patent JP2009529572

Kind Code:

A

Abstract:

The present invention relates to novel derivatives of 18beta-glycyrrhetinic acid and methods of synthesising the derivatives. Also included within the scope of the present invention are pharmaceutical compositions comprising the derivatives of the present invention and medical uses of the derivatives, including their use in inhibiting enzymes such as retinol dehydrogenases. The present invention also relates to methods of treating diseases, such as hyperproliferative diseases, neoplasms, cancers and photoageing.

Inventors:

Simon Ward
Alice McGowan
Stanley Roberts
Jenny Little Child
Kirsty Line
Ed Irving
Sam Donnelly

Application Number:

JP2008558912A

Publication Date:

August 20, 2009

Filing Date:

March 09, 2007

Export Citation:

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Assignee:

York Pharma PLC

International Classes:

C07J63/00; A61K31/225; A61K31/235; A61K31/4965; A61P1/16; A61P9/10; A61P15/00; A61P17/00; A61P17/06; A61P17/14; A61P19/00; A61P19/10; A61P25/24; A61P31/12; A61P31/14; A61P31/18; A61P35/00; A61P37/02; A61P43/00

Domestic Patent References:

JPS6058942A	1985-04-05
JP2004506691A	2004-03-04
JPS63135351A	1988-06-07
JPH04352755A	1992-12-07

Foreign References:

GB1387499A	1975-03-19
DE1076684B	1960-03-03

Other References:

JPN5009004768; Ｂｉｏｃｈｅｍｉｃａｌ　ＰｈａｒｍａｃｏｌｏｇｙＶｏｌ．１９，　Ｎｏ．８, 1970, ｐ．２５０１-２５０７
JPN6012048276; 応用薬理第１１巻第５号, 1975, 第６７７-６９２頁
JPN7012003750; Ｂｒｉｔｉｓｈ　Ｊｏｕｒｎａｌ　ｏｆ　ＰｈａｒｍａｃｏｌｏｇｙＶｏｌ．９６，　Ｎｏ．１, 1989, ｐ．２０４-２１０
JPN7012003751; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２７０，　Ｎｏ．４７, 1995, ｐ．２８４０８-２８４１２
JPN6012048274; Ｊｏｕｒｎａｌ　ｏｆ　Ｏｌｅｏ　ＳｃｉｅｎｃｅＶｏｌ．５１，　Ｎｏ．５, 2002, ｐ．３１３-３２１
JPN5009004772; Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ　ＪｏｕｒｎａｌＶｏｌ．３５，　Ｎｏ．５, 2001, ｐ．２４３-２４６

Attorney, Agent or Firm:

Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro

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