Title:
結合親和性の検出に使用するデバイス
Document Type and Number:
Japanese Patent JP7251892
Kind Code:
B2
Abstract:
A device for use in the detection of binding affinities comprises a substrate, a planar waveguide arranged thereon and having an outer surface. The device further comprises a grating for coupling coherent light of a predetermined wavelength into the planar waveguide such that the coherent light coupled into the planar waveguide propagates through the planar waveguide in a predetermined propagation direction. An evanescent field of the coherent light propagates along the outer surface of the planar waveguide. The outer surface of the planar waveguide has receptor molecules arranged thereon capable of binding target samples to the receptor molecules such that light of the evanescent field is diffracted by the target samples bound to the receptor molecules. The receptor molecules are arranged along a plurality of straight parallel lines such that a portion of the light of the evanescent field is diffracted by the target samples bound to the receptor molecules.
Inventors:
Fattinger, Christoph
Application Number:
JP2020541757A
Publication Date:
April 04, 2023
Filing Date:
February 28, 2019
Export Citation:
Assignee:
F. Hoffman-La Roche Age
International Classes:
G01N21/47; G01N21/17; G01N33/543; G02B5/18
Domestic Patent References:
| JP2015503757A | ||||
| JP2016524163A | ||||
| JP2015536471A | ||||
| JP2016505140A | ||||
| JP7169088A | ||||
| JP8285851A | ||||
| JP2010540924A | ||||
| JP63277969A | ||||
| JP2003528311A | ||||
| JP2017503203A |
Foreign References:
| WO2015111458A1 |
Other References:
GATTERDAM, V. et al,,Focal molography is a new method for the in situ analysis of molecular interactions in biological samples,Nature Nanotechnology,2017年,Vol.12,pp.1-8,DOI: 10.1038/nnano.2017.168
FATTINGER, C.,Focal Molography: Coherent Microscopic Detection of Biomolecular Interaction,PHYSICAL REVIEW X,2014年,Vol.4,pp.031024-1~031024-13,DOI: 10.1103/PhysRevX.4.031024
LAI, Z. et al.,Label-free biosensor by protein grating coupler on planar optical waveguides,Optics Letters,Vol. 33, Issue 15,pp. 1735-1737,https://doi.org/10.1364/OL.33.001735
FATTINGER, C.,Focal Molography: Coherent Microscopic Detection of Biomolecular Interaction,PHYSICAL REVIEW X,2014年,Vol.4,pp.031024-1~031024-13,DOI: 10.1103/PhysRevX.4.031024
LAI, Z. et al.,Label-free biosensor by protein grating coupler on planar optical waveguides,Optics Letters,Vol. 33, Issue 15,pp. 1735-1737,https://doi.org/10.1364/OL.33.001735
Attorney, Agent or Firm:
Patent Attorney Corporation MM&A
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