Title:
EXCELLENT CONTROL OF BLOOD GLUCOSE IN DIABETES TREATMENT
Document Type and Number:
Japanese Patent JP2015110631
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a composition which enables homeostatic control of postprandial glucose levels while reducing the risk of hypoglycemia, and enables excellent control in blood glucose levels mimicking the insulin release kinetics of a non-diabetic individual.SOLUTION: The invention relates to a composition which is suitable for pulmonary administration, increases to a peak of serum insulin concentration within 15 minutes from administration and decreases to a half maximal level within 80 minutes from administration, is capable of suppressing postprandial blood glucose fluctuation, as well as consists of microparticles comprising diketopiperazine and insulin. The invention also relates to a method for administering the insulin composition within approximately 10 minutes prior to beginning a meal to approximately 30 minutes after beginning a meal.
Inventors:
CHEATHAM WAYMAN WENDELL
BOSS ANDERS
BOSS ANDERS
Application Number:
JP2015020034A
Publication Date:
June 18, 2015
Filing Date:
February 04, 2015
Export Citation:
Assignee:
MANNKIND CORP
International Classes:
A61K38/28; A61K9/72; A61K47/22
Domestic Patent References:
| JP2003503420A | 2003-01-28 | |||
| JP2003503420A | 2003-01-28 | |||
| JP5788374B2 | 2015-09-30 |
Other References:
JPN6014002961; 稲田千鶴子ら: ''インスリン療法'' 臨床と研究 ７２巻１号 （１９９５）, ３６-３９
JPN6014002962; 荒木栄一ら: ''インスリン療法の基本'' 臨床と研究 ７９巻１号 （２００２）, ３８-４２
JPN6014002963; 岩本安彦: ''糖尿病治療のストラテジー'' 医学のあゆみ Ｖｏｌ．１８８， Ｎｏ．５ （１９９９）, ４７２-４７６
JPN6014002959; Ｓ．Ｓｔｅｉｎｅｒ ｅｔ ａｌ．: ''Ｔｅｃｈｎｏｓｐｈｅｒｅ／Ｉｎｓｕｌｉｎ--ｐｒｏｏｆ ｏｆ ｃｏｎｃｅｐｔ ｓｔｕｄｙ ｗｉｔｈ ａ ｎｅｗ ｉｎｓｕｌｉｎ ｆｏｒｍｕｌａｔｉｏｎ ｆｏｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ'' Ｅｘｐ Ｃｌｉｎ Ｅｎｄｏｃｒｉｎｏｌ Ｄｉａｂｅｔｅｓ ２００２；１１０（１）, １７-２１
JPN6014002960; Ｌｉｎｄｎｅｒ ｅｔ ａｌ．: ''Ｉｎｃｒｅａｓｅ ｉｎ ｓｅｒｕｍ ｉｎｓｕｌｉｎ ｌｅｖｅｌｓ ｉｓ ｃｏｒｒｅｌａｔｅｄ ｗｉｔｈ ｌｕｎｇ ｄｉｓｔｒｉｂｕｔｉｏｎ ａｆｔｅｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ ｏｆ Ｔ' Ｄｉａｂｅｔｏｌｏｇｉａ ２００３ Ｎｏ．４６, Ａ２７７
JPN6010065295; Ｄｉａｂｅｔｅｓ Ｔｅｃｈｎｏｌ Ｔｈｅｒ Ｖｏｌ．４, 2002, ｐｐ．５８９-９４
JPN6010065296; Ｄｉａｂｅｔｏｌｏｇｉａ Ｖｏｌ．４４（Ｓｕｐｐｌ．１）, 2001, ｐ．Ａ２１２
JPN6014002959; Ｓ．Ｓｔｅｉｎｅｒ ｅｔ ａｌ．: ''Ｔｅｃｈｎｏｓｐｈｅｒｅ／Ｉｎｓｕｌｉｎ--ｐｒｏｏｆ ｏｆ ｃｏｎｃｅｐｔ ｓｔｕｄｙ ｗｉｔｈ ａ ｎｅｗ ｉｎｓｕｌｉｎ ｆｏｒｍｕｌａｔｉｏｎ ｆｏｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ'' Ｅｘｐ Ｃｌｉｎ Ｅｎｄｏｃｒｉｎｏｌ Ｄｉａｂｅｔｅｓ ２００２；１１０（１）, １７-２１
JPN6014002960; Ｌｉｎｄｎｅｒ ｅｔ ａｌ．: ''Ｉｎｃｒｅａｓｅ ｉｎ ｓｅｒｕｍ ｉｎｓｕｌｉｎ ｌｅｖｅｌｓ ｉｓ ｃｏｒｒｅｌａｔｅｄ ｗｉｔｈ ｌｕｎｇ ｄｉｓｔｒｉｂｕｔｉｏｎ ａｆｔｅｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ ｏｆ Ｔ' Ｄｉａｂｅｔｏｌｏｇｉａ ２００３ Ｎｏ．４６, Ａ２７７
JPN6016032319; Ｕｗａｉｆｏ ＧＩ， Ｒａｔｎｅｒ ＲＥ: 'Ｎｏｖｅｌ ｐｈａｒｍａｃｏｌｏｇｉｃ ａｇｅｎｔｓ ｆｏｒ ｔｙｐｅ ２ ｄｉａｂｅｔｅｓ' Ｅｎｄｏｃｒｉｎｏｌｏｇｙ ａｎｄ Ｍｅｔａｂｏｌｉｓｍ Ｃｌｉｎｉｃｓ ｏｆ Ｎｏｒｔｈ Ａｍｅｒｉｃａ Ｖｏｌ．３４， Ｎｏ．１, 20050304, ｐ．１５５-１９７
JPN6014002962; 荒木栄一ら: ''インスリン療法の基本'' 臨床と研究 ７９巻１号 （２００２）, ３８-４２
JPN6014002963; 岩本安彦: ''糖尿病治療のストラテジー'' 医学のあゆみ Ｖｏｌ．１８８， Ｎｏ．５ （１９９９）, ４７２-４７６
JPN6014002959; Ｓ．Ｓｔｅｉｎｅｒ ｅｔ ａｌ．: ''Ｔｅｃｈｎｏｓｐｈｅｒｅ／Ｉｎｓｕｌｉｎ--ｐｒｏｏｆ ｏｆ ｃｏｎｃｅｐｔ ｓｔｕｄｙ ｗｉｔｈ ａ ｎｅｗ ｉｎｓｕｌｉｎ ｆｏｒｍｕｌａｔｉｏｎ ｆｏｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ'' Ｅｘｐ Ｃｌｉｎ Ｅｎｄｏｃｒｉｎｏｌ Ｄｉａｂｅｔｅｓ ２００２；１１０（１）, １７-２１
JPN6014002960; Ｌｉｎｄｎｅｒ ｅｔ ａｌ．: ''Ｉｎｃｒｅａｓｅ ｉｎ ｓｅｒｕｍ ｉｎｓｕｌｉｎ ｌｅｖｅｌｓ ｉｓ ｃｏｒｒｅｌａｔｅｄ ｗｉｔｈ ｌｕｎｇ ｄｉｓｔｒｉｂｕｔｉｏｎ ａｆｔｅｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ ｏｆ Ｔ' Ｄｉａｂｅｔｏｌｏｇｉａ ２００３ Ｎｏ．４６, Ａ２７７
JPN6010065295; Ｄｉａｂｅｔｅｓ Ｔｅｃｈｎｏｌ Ｔｈｅｒ Ｖｏｌ．４, 2002, ｐｐ．５８９-９４
JPN6010065296; Ｄｉａｂｅｔｏｌｏｇｉａ Ｖｏｌ．４４（Ｓｕｐｐｌ．１）, 2001, ｐ．Ａ２１２
JPN6014002959; Ｓ．Ｓｔｅｉｎｅｒ ｅｔ ａｌ．: ''Ｔｅｃｈｎｏｓｐｈｅｒｅ／Ｉｎｓｕｌｉｎ--ｐｒｏｏｆ ｏｆ ｃｏｎｃｅｐｔ ｓｔｕｄｙ ｗｉｔｈ ａ ｎｅｗ ｉｎｓｕｌｉｎ ｆｏｒｍｕｌａｔｉｏｎ ｆｏｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ'' Ｅｘｐ Ｃｌｉｎ Ｅｎｄｏｃｒｉｎｏｌ Ｄｉａｂｅｔｅｓ ２００２；１１０（１）, １７-２１
JPN6014002960; Ｌｉｎｄｎｅｒ ｅｔ ａｌ．: ''Ｉｎｃｒｅａｓｅ ｉｎ ｓｅｒｕｍ ｉｎｓｕｌｉｎ ｌｅｖｅｌｓ ｉｓ ｃｏｒｒｅｌａｔｅｄ ｗｉｔｈ ｌｕｎｇ ｄｉｓｔｒｉｂｕｔｉｏｎ ａｆｔｅｒ ｐｕｌｍｏｎａｒｙ ｄｅｌｉｖｅｒｙ ｏｆ Ｔ' Ｄｉａｂｅｔｏｌｏｇｉａ ２００３ Ｎｏ．４６, Ａ２７７
JPN6016032319; Ｕｗａｉｆｏ ＧＩ， Ｒａｔｎｅｒ ＲＥ: 'Ｎｏｖｅｌ ｐｈａｒｍａｃｏｌｏｇｉｃ ａｇｅｎｔｓ ｆｏｒ ｔｙｐｅ ２ ｄｉａｂｅｔｅｓ' Ｅｎｄｏｃｒｉｎｏｌｏｇｙ ａｎｄ Ｍｅｔａｂｏｌｉｓｍ Ｃｌｉｎｉｃｓ ｏｆ Ｎｏｒｔｈ Ａｍｅｒｉｃａ Ｖｏｌ．３４， Ｎｏ．１, 20050304, ｐ．１５５-１９７
Attorney, Agent or Firm:
Kimura Mitsuru
Takanori Mamoru
Taiji Morikawa
Kei Sakurada
Mie Hideki
Takanori Mamoru
Taiji Morikawa
Kei Sakurada
Mie Hideki