FIBRIN COMPOSITION CONTAINING STRONTIUM COMPOUND

Title:

FIBRIN COMPOSITION CONTAINING STRONTIUM COMPOUND

Document Type and Number:

Japanese Patent JP2013216678

Kind Code:

A

Abstract:

To provide a composition for use in bone healing and bone regeneration.

There is provided a composition for use in bone healing and bone regeneration in the form of a viscoelastic hydrogel gel or liquid formulation comprising fibrinogen, thrombin and an inorganic component comprising a strontium (Sr)-containing compound. The strontium-containing compound can be dissolved in thrombin solutions or added to clot in crystalline particulate form. Upon mixing the components, gelation takes place to form a matrix. The composition may also comprise an iodine-containing compound which acts as a plasticizer.

Inventors:

BARRY JOHN J
GOESSL ANDREAS
ZIMMER GERALD

Application Number:

JP2013130650A

Publication Date:

October 24, 2013

Filing Date:

June 21, 2013

Export Citation:

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Assignee:

BAXTER INT
BAXTER HEALTHCARE SA

International Classes:

A61K33/14; A61K9/06; A61K9/08; A61K31/19; A61K31/198; A61K31/663; A61K38/00; A61K38/17; A61K38/22; A61K38/35; A61K38/48; A61K47/10; A61K47/16; A61K47/26; A61K47/34; A61K47/36; A61P19/08

Domestic Patent References:

JP2008526810A	2008-07-24
JP2001527020A	2001-12-25
JP2005531341A	2005-10-20

Foreign References:

WO2006072622A2

2006-07-13

Other References:

JPN6014000272; ＭＡＲＩＥ，　Ｐ．Ｊ．　ｅｔ　ａｌ: 'Ａｎ　ｕｎｃｏｕｐｌｉｎｇ　ａｇｅｎｔ　ｃｏｎｔａｉｎｉｎｇ　ｓｔｒｏｎｔｉｕｍ　ｐｒｅｖｅｎｔｓ　ｂｏｎｅ　ｌｏｓｓ　ｂｙ　ｄｅｐｒｅｓｓｉｎｇ　ｂｏｎｅ　ｒｅｓｏｒｐｔｉｏｎ　ａｎｄ　ｍａｉｎｔａ' Ｊ．　Ｂｏｎｅ　Ｍｉｎｅｒ．　Ｒｅｓ．Ｖｏｌ．８，　Ｎｏ．５, 1993, ｐ．６０７-６１５
JPN6014049592; Ｊ．　Ｂｉｏｍｅｄ．　Ｍａｔｅｒ．　Ｒｅｓ．　Ａ．　２００４，　Ｖｏｌ．７０，　Ｎｏ．３，　ｐ．４２８-４３５
JPN6014049593; Ｊ．　Ｂｉｏｍｅｄ．　Ｍａｔｅ．ｒ　Ｒｅｓ．　Ａ．　２００６，　Ｖｏｌ．７９，　Ｎｏ．４，　ｐ．８０４-８１４

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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