METHOD FOR TREATING AUTOIMMUNE DISEASE

Title:

METHOD FOR TREATING AUTOIMMUNE DISEASE

Document Type and Number:

Japanese Patent JP2013216677

Kind Code:

A

Abstract:

To provide a method for treatment of patients suffering from autoimmune diseases such as systemic erythematodes and multiple sclerosis.

Provided is a method that includes: (a) depletion of circulating lymphocytes in a mammal by administering a factor selected from a group consisting of anti-thymus cell antibody, anti-CD52 antibody, and anti-CD3 antibody; (b) causing lymphoid rebuilding to be initiated; and (c) an administration in the (b) rebuilding phase to the mammal of a therapeuticalkly effective amount of latent-form TGF-βand/or a separate factor, such as dexamethasone and rapamycin, that promotes the growth of regulatory T cel.

Inventors:

KAPLAN JOHANNE
MCPHERSON JOHN M

Application Number:

JP2013130526A

Publication Date:

October 24, 2013

Filing Date:

June 21, 2013

Export Citation:

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Assignee:

GENZYME CORP

International Classes:

A61K38/00; A61K31/343; A61K31/436; A61K31/573; A61K31/593; A61K39/395; A61K45/00; A61P13/12; A61P37/02; A61P37/06; A61P43/00; C07K14/495; C07K16/28

Domestic Patent References:

JPH01287039A	1989-11-17
JP2002128690A	2002-05-09

Other References:

JPN7012001695; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡｖｏｌ．９５, 1998, ｐ．１２５１６-１２５２１
JPN6012023496; Ｊｏｕｒｎａｌ　ｏｆ　Ｌｅｕｋｏｃｙｔｅ　Ｂｉｏｌｏｇｙｖｏｌ．７９, 200601, ｐ．１４０-１４６
JPN6012023497; ｎｅｕｒｏｌｏｇｙｖｏｌ．５１，　ｎｏ．１, 1998, ｐ．２８９-２９２
JPN7012001696; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡｖｏｌ．８８, 1991, ｐ．２９１８-２９２１
JPN6012023498; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　ｉｎｔｅｒｎａｔｉｏｎａｌ　ｍｅｄｉｃａｌ　ｒｅｓｅａｒｃｈｖｏｌ．２５，　ｎｏ．４, 1997, ｐ．２１９-２３
JPN6013002736; Ｓｃａｎｄ　Ｊ　Ｒｈｅｕｍａｔｏｌｖｏｌ．２２，　ｎｏ．６, 199302, ｐ．２６１-６

Attorney, Agent or Firm:

Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Nakahama

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