CYTOMODULATING CONJUGATE OF MEMBER OF SPECIFIC BINDING PAIR

Japanese Patent JP3105629

B2

PURPOSE: To obtain a conjugate capable of selectively activating or inactivating a cell group of an immune system, and containing a moiety capable of binding to a target cell receptor and a moiety capable of binding to an effector agent.
CONSTITUTION: A target cell is inactivated by introducing a conjugate to a host including an endogenous cytotoxic effector system containing at least one effector agent. The con jugate contains a moiety specific to a surface membrane receptor combined to a selective moiety (e.g. blood type antigen) capable of forming a cell-inactivating complex by binding to the effector system. When the selective moiety binds to a T-cell, the moiety binds to a T-cell receptor, and the effector system contains an antibody-dependent cytotoxin system containing the antibody specific to the selective moiety, and the effector agent, or the T-cell. The cell is inactivated when binding to the target cell of the conjugate and the effector agent.

WO/2003/057726	Cytotoxic cyplasin of the sea hare, Aplysia punctata, cDNA cloning and expression of bioreactive recombinants
JP4621142	HLA-DR binding antigen peptide derived from WT1
WO/2005/113823	HYALURONAN RECEPTOR FOR ENDOCYTOSIS, VARIANTS THEREOF, AND METHODS OF MAKING AND USING SAME

Philip Pouretti

JP8922392A

November 06, 2000

April 10, 1992

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Sangustat Medical Corporation

A61K38/00; A61K39/385; G01N33/53; A61K39/44; A61K47/48; A61P37/06; G01N33/564; (IPC1-7): A61K39/385; A61P37/06

JP2169521A

Aoki Akira (3 outside)

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