GENE EXPRESSION PROFILE ALGORITHM AND TEST FOR LIKELIHOOD OF RECURRENCE OF COLORECTAL CANCER AND RESPONSE TO CHEMOTHERAPY

Title:

GENE EXPRESSION PROFILE ALGORITHM AND TEST FOR LIKELIHOOD OF RECURRENCE OF COLORECTAL CANCER AND RESPONSE TO CHEMOTHERAPY

Document Type and Number:

Japanese Patent JP2016104014

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide information on the likelihood of recurrence of colorectal cancer in a patient and/or likelihood of beneficial response to chemotherapy comprising measurement of the expression levels of prognostic and/or predictive genes derived from a biological sample obtained from a cancer patient, and analysis of the measured expression levels.SOLUTION: Provided is a method for determining a likelihood of cancer recurrence after surgery in a patient with colorectal cancer, which comprises the steps of: measuring expression levels of prognostic genes in a tumor sample obtained from the patient; calculating a recurrence score (RS) for the patient using the measured gene expression levels, wherein the RS is calculated by assigning the measured expression levels to gene subsets of an RS algorithm, wherein the gene subsets comprise at least one gene each from a stromal group and a cell cycle group; and generating a report based on the RS.SELECTED DRAWING: Figure 1-1

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Inventors:

SHAK STEVEN
WATSON DREW
LI XITONG
LAWRENCE LEE
KIM LANGONE

Application Number:

JP2015247014A

Publication Date:

June 09, 2016

Filing Date:

December 18, 2015

Export Citation:

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Assignee:

GENOMIC HEALTH INC

International Classes:

C12Q1/68; C12N15/09; G01N33/68; G16Z99/00

Domestic Patent References:

JP2009523028A	2009-06-18
JP2012508805A	2012-04-12

Foreign References:

WO2007082099A2	2007-07-19
US20030148314A1	2003-08-07
WO2003050243A2	2003-06-19
WO2010127322A1	2010-11-04

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Attorney, Agent or Firm:

Naoto Uchida

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