Title:
HIVプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2010540517
Kind Code:
A
Abstract:
Compounds of Formula I are disclosed: (I), wherein XA, k, R1, R2, R3, R4, R5, R5A, R6, R6A, R7 and R8 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Inventors:
Cobain, craig aye
Batka, Joseph P
Radija Pakshi, Hemaka A
Kristen El Gee
Nan Therme, Philip
Barrow, The Ames Sea
Moore, Keith Pee
Syalik, Stephen S
Severage, Corey
Warzi, Atsuba M
Batka, Joseph P
Radija Pakshi, Hemaka A
Kristen El Gee
Nan Therme, Philip
Barrow, The Ames Sea
Moore, Keith Pee
Syalik, Stephen S
Severage, Corey
Warzi, Atsuba M
Application Number:
JP2010526914A
Publication Date:
December 24, 2010
Filing Date:
September 22, 2008
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07C311/18; A61K31/18; A61K31/27; A61K31/352; A61K31/428; A61K31/4409; A61P31/18; C07C311/29; C07C311/41; C07D213/30; C07D277/62; C07D311/82
Attorney, Agent or Firm:
Kawaguchi International Patent Office