Title:
C型肝炎ウイルスNS5Bポリメラーゼインヒビター結合ポケット
Document Type and Number:
Japanese Patent JP4584909
Kind Code:
B2
Abstract:
The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a conformation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.
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Inventors:
Kronbrune
Beaulieu Pierre Louis
Jolicourt Eric
Kukoly Georges
La Plante Stephen
Pupard Marc Andre
Beaulieu Pierre Louis
Jolicourt Eric
Kukoly Georges
La Plante Stephen
Pupard Marc Andre
Application Number:
JP2006500449A
Publication Date:
November 24, 2010
Filing Date:
May 05, 2004
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C12N9/12; C07D405/14; C07K14/18; C12N5/08; C12N15/09
Domestic Patent References:
| JP2003061685A | ||||
| JP2006517536A | ||||
| JP2002513562A | ||||
| JP11508362A |
Foreign References:
| WO2002004425A1 | ||||
| WO2003007945A1 |
Other References:
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Proc. Natl. Acad. Sci. USA,1999年,Vol. 96,p. 13034-13039
The Journal of Biological Chemistry,2002年,Vol. 277,p. 38322-38327
The Journal of Biological Chemistry,2002年,Vol. 277,p. 38838-38846
Journal of Med. Chem.,2001年,Vol. 44,p. 4615-4627
Journal of Med. Chem.,2000年,Vol. 43,p. 2664-2674
FEBS Letters,2001年,Vol. 502,p. 93-97
Protein Science,2003年 4月,Vol. 12,p. 784-793
Current Opinion in Chemical Biology,1997年,Vol. 1,p. 157-161
Proc. Natl. Acad. Sci. USA,1999年,Vol. 96,p. 13034-13039
The Journal of Biological Chemistry,2002年,Vol. 277,p. 38322-38327
The Journal of Biological Chemistry,2002年,Vol. 277,p. 38838-38846
Journal of Med. Chem.,2001年,Vol. 44,p. 4615-4627
Journal of Med. Chem.,2000年,Vol. 43,p. 2664-2674
FEBS Letters,2001年,Vol. 502,p. 93-97
Protein Science,2003年 4月,Vol. 12,p. 784-793
Current Opinion in Chemical Biology,1997年,Vol. 1,p. 157-161
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai