Title:
HETEROCYCLIC RING-CONTAINING CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP3476883
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound, having the ability to bind to retinoid receptors and antagonistic action on retinoids and useful for treating various diseases such as dyskeratosis or chronic articular rheumatism.
CONSTITUTION: This compound is expressed by formula I {ring D is expressed by formula II (R1 and R2 are H, lower alkyl, halogen, etc.; Ra and Rb are H, lower alkoxy, etc.); ring B is expressed by formula III (R6 is H, lower alkyl, etc.; R7 is expressed by formula IV; G is phenylene, etc.; R8 is H, OH, etc.), etc.; A is O, S SO2, etc.; E is (CH2)n [n is 0-2], CHCH3, etc.}, e.g. 4-[4,5,7,8,9,10- hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra[1,2-blpyrrol-3-yl-benzoic acid. The compound expressed by formula I is obtained by reacting a compound expressed by formula V with a compound expressed by formula VI in the presence of a base (e.g. lithium diisopropylamide) in a solvent (e.g. THF) at -78°C to the boiling point of the solvent.
Inventors:
Hiroyuki Yoshimura
Mitsuo Nagai
Shigeki Hibi
Koichi Kikuchi
Hishinuma Uharu
Junichi Nagakawa
Makoto Asada
Noriyuki Miyamoto
Takayuki Hidan
Aichi Ogasawara
Isao Yamazu
Mitsuo Nagai
Shigeki Hibi
Koichi Kikuchi
Hishinuma Uharu
Junichi Nagakawa
Makoto Asada
Noriyuki Miyamoto
Takayuki Hidan
Aichi Ogasawara
Isao Yamazu
Application Number:
JP32151793A
Publication Date:
December 10, 2003
Filing Date:
December 21, 1993
Export Citation:
Assignee:
Eisai Co., Ltd.
International Classes:
A61K31/34; A61K31/343; A61K31/38; A61K31/381; A61K31/382; A61K31/40; A61K31/403; A61K31/415; A61K31/4184; A61K31/42; A61K31/423; A61K31/425; A61K31/428; A61K31/44; A61K31/4427; A61K31/443; A61K31/47; A61K31/473; A61P1/16; A61P5/12; A61P17/00; A61P17/14; A61P19/00; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C69/76; C07C211/31; C07D209/56; C07D209/58; C07D215/04; C07D221/06; C07D221/16; C07D221/18; C07D231/54; C07D235/02; C07D261/20; C07D277/60; C07D335/08; C07D307/77; C07D307/92; C07D311/92; C07D333/38; C07D333/50; C07D335/06; C07D401/04; C07D401/06; C07D401/14; C07D403/04; C07D403/06; C07D405/06; C07D409/06; C07D409/14; C07D417/04; C07D471/04; C07D487/04; C07D491/04; C07D491/044; C07D491/048; C07D491/052; C07D493/04; C07D495/04; C07D498/04; C07D513/04; (IPC1-7): C07D231/54; C07C69/76; C07D209/56; C07D209/58; C07D221/06; C07D221/16; C07D221/18; C07D235/02; C07D261/20; C07D277/60; C07D307/77; C07D307/92; C07D311/92; C07D333/38; C07D333/50; C07D335/06; C07D401/06; C07D405/06; C07D417/04; C07D487/04; C07D491/044; C07D491/048; C07D491/052; C07D493/04; C07D495/04; C07D498/04; C07D513/04
Attorney, Agent or Firm:
Kaoru Furuya (3 outside)