HIGHLY STABILIZED CONTROLLED RELEASE FORMULATIONS HAVING ACRYLIC POLYMER COATING AND ITS PRODUCTION

Japanese Patent JP3957329

B2

PURPOSE: To obtain a controlled release formulations for oral administration having an acrylic polymer coating formed from an aqueous acrylic polymer suspension so that substantially stabilized solubilization profile may be obtained even under a variety of storage conditions.
CONSTITUTION: The base containing therapeutically active agents is coated with a water-based suspension of a plasticized acrylic polymer and the coated base is cured at a temperature that is higher than the glass transition point of the plasticized acrylic polymer until the coated base acquires highly stabilized dissolution profile which is hardly affected even under elevated temperature and/or elevated relative humidity conditions whereby the objective stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of an acrylic polymer is obtained.

JP3605654	Solid grain coating method and equipment
JPH07328409	PROCESS AND APPARATUS FOR GRANULATION OF GRANULATABLE AND/OR PELLETIZABLE SUBSTANCE
JP2007525252	Equipment equipped with machines for manufacturing tablets for treatment in particular

Benjamin Oshurak
Mark chaisin
Frank peddy, junior

JP21913392A

August 15, 2007

August 18, 1992

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Euro-Certique S.A.

A61J3/06; A61K9/22; A61K9/28; A61K9/32; A61K9/50; A61K9/52; A61K9/54; A61K9/58; A61K9/62; A61M37/00; (IPC1-7): A61K9/28; A61J3/06; A61K9/32; A61K9/58; A61M37/00

医薬品添加物ハンドブック、丸善株式会社、日本薬学会訳編、平成元年3月30日発行、p.359-361

Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Yasuhito Suzuki

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