Title:
メデトミジンおよびその塩類を調製する方法
Document Type and Number:
Japanese Patent JP2010508332
Kind Code:
A
Abstract:
The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagents and the subsequent reaction with 2,3-dimethylbenzaldehyde.
Inventors:
Reine, Ines
Zandersons, Armand
Zandersons, Armand
Application Number:
JP2009535083A
Publication Date:
March 18, 2010
Filing Date:
November 02, 2007
Export Citation:
Assignee:
GRINDEKS,a joint stock company
International Classes:
C07D233/58; C07D233/64; C07B61/00
Domestic Patent References:
| JPS5818365A | 1983-02-02 |
Foreign References:
| WO2006036480A1 | 2006-04-06 | |||
| WO2006036497A2 | 2006-04-06 |
Other References:
JPN5009017685; Ｒ． Ｍ． ＴＵＲＮＥＲ: Ｊ． ＯＲＧ． ＣＨＥＭ． Ｖ５６, 1991, Ｐ５７３９-５７４０
JPN5009017684; ＺＨＡＮＧ Ｘ: ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ３９, 1996, Ｐ３００１-３０１３, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN5009017686; ＣＯＲＤＩ Ａ Ａ: ＳＹＮＴＨＥＴＩＣ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ Ｖ２６ Ｎ８, 1996, Ｐ１５８５-１５９３, ＭＡＲＣＥＬ ＤＥＫＫＥＲ ＩＮＣ．
JPN5009017684; ＺＨＡＮＧ Ｘ: ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ３９, 1996, Ｐ３００１-３０１３, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN5009017686; ＣＯＲＤＩ Ａ Ａ: ＳＹＮＴＨＥＴＩＣ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ Ｖ２６ Ｎ８, 1996, Ｐ１５８５-１５９３, ＭＡＲＣＥＬ ＤＥＫＫＥＲ ＩＮＣ．
Attorney, Agent or Firm:
Keiichi Ota