Title:
【発明の名称】プロテアーゼインヒビターとしてのアミジノヒドラゾン
Document Type and Number:
Japanese Patent JP2000507588
Kind Code:
A
Abstract:
Amidino and benzamidino compounds, including compounds of the formula: I wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.
Inventors:
Sol, Richard M.
Rou, Tian Bao
Feddy, Cynthia El.
Tom Chuck, Bruce E.
Curl
Rou, Tian Bao
Feddy, Cynthia El.
Tom Chuck, Bruce E.
Curl
Application Number:
JP53552597A
Publication Date:
June 20, 2000
Filing Date:
March 27, 1997
Export Citation:
Assignee:
3-Dimensional Pharmaceuticals, Incorporated
International Classes:
A61K31/00; A61K31/165; A61K31/18; A61K31/275; A61K31/277; A61K31/41; A61K31/415; A61K31/433; A61K31/44; A61K31/4406; A61K31/47; A61K31/472; A61P1/00; A61P1/18; A61P7/00; A61P7/02; A61P43/00; C07C45/29; C07C45/71; C07C47/277; C07C281/18; C07C309/67; C07C309/73; C07C309/74; C07C309/75; C07C309/77; C07C311/21; C07C323/66; C07D213/70; C07D213/71; C07D215/36; C07D217/02; C07D231/14; C07D231/18; C07D233/52; C07D285/14; C07D317/40; C07D333/34; (IPC1-7): C07C281/18; A61P1/18; A61P7/02; A61P43/00; A61K31/165; A61K31/18; A61K31/277; A61K31/433; A61K31/415; A61K31/4406; A61K31/47; A61K31/472; C07C309/67; C07C309/73; C07C309/74; C07C309/75; C07C309/77; C07C311/21; C07D213/70; C07D215/36; C07D217/02; C07D231/14; C07D285/14
Attorney, Agent or Firm:
Shusaku Yamamoto