【発明の名称】抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体

Title:

【発明の名称】抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体

Document Type and Number:

Japanese Patent JP3333510

Kind Code:

B2

Abstract:

Compounds illustrated by general formula (I) useful as PDE IV inhibitors and for inhibiting the production of Tumor Necrosis Factor (TNF) are disclosed herein. In formula (I) R1 is C1-12 alkyl unsubstituted or substituted by 1 or more halogens; C3-6 cyclic alkyl unsubstituted or substituted by 1 to 3 methyl groups or one ethyl group; C4-6 cycloalkyl containing one or two unsaturated bonds; C7-11 polycycloalkyl, -(CR14R14)nC(O)-O-(CR14R14)m-R10, -(CR14R14)nC(O)-O-(CR14R14)r-R11, -(CR14R14)xOH, -(CR14R14)sO(CR14R14)m-R10, -(CR14R14)sO(CR14R14)r-R11, -(CR14R14)n-(C(O)NR14)-(CR14R14)m-R10, -(CR14R14)n-(C(O)NR14)-(CR14R14)r-R11, -(CR14R14)y-R11 or -(CR14R14)z-R10; X2 is O or NR14; X3 is hydrogen or X; X is YR2, halogen, nitro, NR14R14 or formamide; Y is O or S(O)m; R2 is -CH3 or -CH2CH3, each may be unsubstituted or substituted by 1 to 5 fluorines; A is (a), (b), (c), (d) or (e); B is >C=Z or C=S.

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Inventors:

Christensen, Siegfried Benjamin, The Force
Levy, Mark Alan

Application Number:

JP50720193A

Publication Date:

October 15, 2002

Filing Date:

October 01, 1992

Export Citation:

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Assignee:

SMITHKLINE BEECHAM CORPORATION

International Classes:

A61K31/122; A61K31/165; A61K31/192; A61K31/194; A61K31/216; A61K31/277; A61K31/41; A61K31/4184; A61K31/4409; A61P11/06; A61P29/00; A61P37/00; A61P37/08; C07C45/62; C07C45/68; C07C45/70; C07C49/753; C07C59/72; C07C62/12; C07C62/34; C07C69/734; C07C69/757; C07C217/52; C07C229/48; C07C233/23; C07C233/25; C07C233/43; C07C235/40; C07C237/42; C07C237/44; C07C251/44; C07C255/46; C07C317/22; C07C317/32; C07C323/24; C07D213/40; C07D235/02; C07D257/04; (IPC1-7): C07C49/753; A61K31/122; A61K31/165; A61K31/192; A61K31/194; A61K31/216; A61K31/277; A61K31/41; A61K31/4184; A61K31/4409; A61P11/06; A61P29/00; A61P37/00; A61P37/08; C07C69/757; C07C233/25; C07C233/43; C07C235/40; C07C237/42; C07C237/44; C07C317/22; C07C317/32; C07C323/24; C07D213/40; C07D235/02; C07D257/04

Other References:

【文献】国際公開91/15451(WO,A1)

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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