Title:
【発明の名称】プレニルアルコールの製造方法
Document Type and Number:
Japanese Patent JP2001514652
Kind Code:
A
Abstract:
Methods for preparing 3-methyl-2-buten-1-ol (prenyl alcohol) from 2-methyl-1,3-butadiene (isoprene) and carboxylic acids are disclosed. Carboxylic acids which can be used in the process have a Ka (relative to water) greater than 10-4; dichloroacetic acid is especially preferred. The process involves the slow (e.g., dropwise) addition of isoprene to the carboxylic acid to form a prenyl ester. The ester-formation reaction proceeds at room temperature in most cases; use of an organic base catalyst, preferably a sodium or potassium salt of the reactant carboxylic acid, improves the yield. The resultant prenyl ester can be converted to prenyl alcohol by reaction with a base. Prenyl alcohol can be readily converted to citral, a chemical intermediate in the synthesis of vitamins A and E, and several widely-used carotenoids.
Inventors:
Bubbler, James, H.
Application Number:
JP53955098A
Publication Date:
September 11, 2001
Filing Date:
January 08, 1998
Export Citation:
Assignee:
Loyola University of Chicago
International Classes:
C07C27/02; C07C29/09; C07C33/03; C07C67/04; C07C69/12; C07C69/22; C07C69/63; (IPC1-7): C07C67/04; C07C27/02; C07C33/03; C07C69/12; C07C69/22; C07C69/63
Attorney, Agent or Firm:
Yoshihiro Tsunoda