Title:
【発明の名称】うっ血性心不全に対して有用なピリダジニルフェニルヒドラゾン
Document Type and Number:
Japanese Patent JP2003527375
Kind Code:
A
Abstract:
Therapeutically active compounds of formula (I) in which R1 to R4 means hydrogen, alkyl, alkenyl, aryl, arylalkyl, carboxyalkyl, hydroxyalkyl or halogenalkyl, or R2 and R3 form a ring of 5-7 carbon atoms. R5 to R9 means hydrogen, alkyl, alkenyl, aryl, arylalkyl, acyl, hydroxy, alkoxy, alkoxycarbonyl, amino, acylamino, alkylamino, aryloxy, halogen, cyano, nitro, carboxy, alkylsulfonyl, sulfonamido or trifluoromethyl, wherein each aryl residue defined above by itself or as a part of another group may be substituted, and pharmaceutically acceptable salts and esters thereof. The compounds increase the calcium sensitivity of contractile proteins of the cardiac muscle and are thus useful in the treatment of congestive heart failure.
Inventors:
Pustunen, Yarmo
Pipuri, Aino
Ruilo, Anne
Nore and pliers
Bextreme, Reiyo
Remberg, Cali
High color, haemo
Levijoki, Yoko
Kahenen, Petri
Kaibora, Yuha
Pipuri, Aino
Ruilo, Anne
Nore and pliers
Bextreme, Reiyo
Remberg, Cali
High color, haemo
Levijoki, Yoko
Kahenen, Petri
Kaibora, Yuha
Application Number:
JP2001567705A
Publication Date:
September 16, 2003
Filing Date:
March 12, 2001
Export Citation:
Assignee:
Orion Corporation
International Classes:
A61K31/50; A61K31/502; A61P9/04; A61P43/00; C07D237/04; C07D237/32; (IPC1-7): C07D237/04; A61K31/50; A61K31/502; A61P9/04; A61P43/00; C07D237/32
Attorney, Agent or Firm:
Sota Asahina (1 person outside)