Title:
【発明の名称】新規の3-アリールインドールおよび3-アリールインダゾール誘導体
Document Type and Number:
Japanese Patent JP3165181
Kind Code:
B2
Abstract:
3-Arylindole or 3-arylindazole derivatives having formula: wherein Ar is optionally substituted phenyl or a heteroaromatic group; R<1>-R<4> are independently selected from hydrogen, halogen, alkyl, alkoxy, hydroxy, nitro, alkylthio, alkylsulphonyl, alkyl- or dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio; the dotted lines designate optional bonds; X is N or a group CR<6> wherein R<6> is hydrogen, halogen, trifluoromethyl or alkyl, or X is CH2; Y is N or CH, or Y is C ; R<5> is hydrogen, cycloalkyl, cycloalkylmethyl, alkyl or alkenyl, optionally substituted with one or two hydroxy groups, or R<5> is a group taken from structures 1a and 1b : wherein n is an integer from 2 - 6; W is O or S; U is N or CH ; Z is -(CH2)m-, m being 2 or 3, -CH=CH- , 1,2-phenylene or -COCH2- or -CSCH2-; V is O, S, CH2, or NR<7>; U<1> is O, S, CH2 or NR<8>; and V<1> is NR<9>R<1><0>, OR<1><1>, SR<1><2> or CR<1><3>R<1><4>R<1><5>, and R<7>-R<1><5> are independently hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkylalkyl ; may be prepared by methods known per se. The compounds are selective centrally acting 5-HT2-antagonists in the brain and are useful in treatment of anxiety, agression, depression, sleep disturbances, migraine, negative symptoms of schizophrenia, drug-induces Parkinsonism and Parkinson's disease.
Inventors:
Yence Cristian Peregard
Kim Andersen
Kim Andersen
Application Number:
JP18892391A
Publication Date:
May 14, 2001
Filing Date:
July 29, 1991
Export Citation:
Assignee:
Her Lundbeck Actiezer Scabet
International Classes:
A61K31/40; A61K31/4427; A61K31/443; A61K31/4433; A61K31/454; A61K31/495; A61K31/496; A61P25/00; A61P25/04; A61P25/18; A61P25/20; A61K31/445; A61P25/24; A61P25/26; C07D209/04; C07D209/08; C07D209/10; C07D231/56; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; (IPC1-7): C07D209/08; A61K31/454; A61P25/00; C07D209/10; C07D231/56; C07D401/04; C07D403/12; C07D405/04; C07D409/04; C07D413/12; C07D417/12
Attorney, Agent or Firm:
Mitsufumi Esaki (2 others)