Title:
【発明の名称】新規コレシストキニンアンタゴニスト、その製造および治療用使用
Document Type and Number:
Japanese Patent JPH06502627
Kind Code:
A
Abstract:
Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.
Inventors:
Howell, David Christopher
Klein Shurrot, Jurgen
Reese, David Chyarles
Richardson, Reginald Stewart
Rourke, William Howard
Roberts, Edward
Loin, Bruce David
Tribeday, Barat Calidas
Holmes, Anne
Padyan, Jyanak Kimchiyand
Klein Shurrot, Jurgen
Reese, David Chyarles
Richardson, Reginald Stewart
Rourke, William Howard
Roberts, Edward
Loin, Bruce David
Tribeday, Barat Calidas
Holmes, Anne
Padyan, Jyanak Kimchiyand
Application Number:
JP51718591A
Publication Date:
March 24, 1994
Filing Date:
August 29, 1991
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
A61K31/35; A61K31/351; A61K31/357; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/425; A61K31/426; A61K31/66; A61K38/00; A61P1/04; A61P25/18; A61P25/30; A61P35/00; C07D209/14; C07D209/16; C07D209/18; C07D209/20; C07D233/20; C07D233/64; C07D249/08; C07D257/04; C07D277/12; A61K31/335; C07D277/20; C07D277/32; C07D309/38; C07D317/18; C07D317/28; C07D317/30; C07D403/12; C07D405/12; C07D413/12; C07D417/12; C07K5/02; C07K5/06; C07K5/065; C07K5/078; C07K5/08; C07K14/575; C07K14/595; C07K14/655; (IPC1-7): C07K5/06; A61K31/335; A61K31/35; A61K31/40; A61K31/415; A61K31/425; A61K31/66; A61K37/02; C07D209/14; C07D209/18; C07D233/20; C07D233/64; C07D249/08; C07D257/04; C07D277/12; C07D277/32; C07D309/38; C07D317/18; C07D317/28; C07D317/30; C07D403/12; C07D405/12; C07D413/12; C07D417/12
Attorney, Agent or Firm:
Chika Takagi (2 outside)