Title:
効果的なワクチンアジュバントとするメバロン酸経路の阻害剤
Document Type and Number:
Japanese Patent JP7076798
Kind Code:
B2
Abstract:
Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjuvant.
Inventors:
Zhang Yonghui
夏 ▲ユン▼
Xie Yonghua
Yu Masamori
Zhou Xiaohong
李 ▲シン▼
Lee Rei Ping
Yang Yun
Takanori
King family
Liu Mari
Zhao Meng
夏 ▲ユン▼
Xie Yonghua
Yu Masamori
Zhou Xiaohong
李 ▲シン▼
Lee Rei Ping
Yang Yun
Takanori
King family
Liu Mari
Zhao Meng
Application Number:
JP2018512602A
Publication Date:
May 30, 2022
Filing Date:
September 08, 2016
Export Citation:
Assignee:
TSINGHUA UNIVERSITY
International Classes:
A61K39/39; A61K31/675; A61P37/04; A61P43/00
Other References:
Oncoimmunology,2013年,Vol.2, No.9,e25636
J Med Chem,2006年,Vol.49, No.25,p.7331-41
J Med Chem,2008年,vol.51, No.21,p.6800-07
J Med Chem,2006年,Vol.49, No.25,p.7331-41
J Med Chem,2008年,vol.51, No.21,p.6800-07
Attorney, Agent or Firm:
Kimura Mitsuru
Yasushi Morikawa
Kei Sakurada
Hideki Mie
Yasushi Morikawa
Kei Sakurada
Hideki Mie
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