Title:
速度論的分割方法
Document Type and Number:
Japanese Patent JP2006509731
Kind Code:
A
Abstract:
A method for stereoselective chemical synthesis, includes the steps of: (A) reacting a nucleophile and chiral or prochiral cyclic subtrate, said substrate comprising a carbocycle or a heterocycle having a reactive center susceptible to nucleophilic attack by the nucleophile, in the presence of a chiral non-racemic catalyst to produce a product mixture comprising a stereomerically enriched product wherein the product mixture further comprises a catalyst residue, at least a portion of the catalyst residue is in a first oxidation state, and the catalyst residue in the first oxidation state is active in catalyzing degradation of the stereoisomerically enriched product, and (B) chemically or electochemically changing the oxidation state of the catalyst residue from the first oxidation state to a second oxidation state, wherein catalyst residue in the second oxidation state is less active in catalyzing degradation of the stereoisomerically enriched product than is catalyst residue in the first oxidation state. The method reduces erosion of the chiral purity of the stereoisomerically enriched product and reduces the chemical transformation to side products of the stereoisomerically enriched product and co-product(s). The deactivated catalyst is recoverable and recyclable.
Inventors:
Lalow, Jay F.
Jasmine, surge
Liu, Yi
Dimere, marcelo
Jasmine, surge
Liu, Yi
Dimere, marcelo
Application Number:
JP2004532533A
Publication Date:
March 23, 2006
Filing Date:
August 27, 2002
Export Citation:
Assignee:
Rhodia Pharma Solutions Inc.
International Classes:
C07D303/04; B01J31/22; C07B53/00; C07B57/00; C07C27/00; C07C29/10; C07D203/06; C07D301/32; C07D303/08; C07D303/48; C07D317/36; C07F7/18; C07F15/06; C07C29/50; C07C29/64; C07C31/34; C07C33/26
Domestic Patent References:
| JP2000053666A | 2000-02-22 |
Foreign References:
| WO2000009463A1 | 2000-02-24 | |||
| WO2001089690A1 | 2001-11-29 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kenichi Kato
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Kenichi Kato
Masaya Nishiyama