Title:
アルツハイマー病の診断及び治療のための材料及び方法
Document Type and Number:
Japanese Patent JP6954839
Kind Code:
B2
Abstract:
Alzheimer's disease (AD) is the most common type of dementia in aging adults with the number of people living with AD projected to increase, making the search for treatments and tools to diagnose and measure disease progression increasingly urgent. In particular, ideal biomarkers for diagnosis of AD should not only have high specificity for disease versus non-disease and high sensitivity for distinguishing between disease types but also should be able to detect changes at a very early stage of the disease. Using microglia activation as an early event of AD's onset, the present inventors have identified a panel of biomarkers in CSF which has the potential to diagnose, stage and determine the likelihood of developing AD.
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Inventors:
Ian Hugo Pique
Claire Louise Russell
Marcolm Ward
Claire Louise Russell
Marcolm Ward
Application Number:
JP2017549301A
Publication Date:
October 27, 2021
Filing Date:
March 17, 2016
Export Citation:
Assignee:
ELECTROPHORETICS LIMITED
International Classes:
C07K14/47; G01N33/68; C07K16/18; C12N5/071; C12N9/10; G01N27/447; G01N27/62; G01N33/53; G01N33/543
Domestic Patent References:
| JP2007502971A | ||||
| JP2013524220A |
Foreign References:
| WO2014135546A1 | ||||
| US20070105105 |
Other References:
Quantification of the Brain Proteome in Alzheimer's Disease Using Multiplexed Mass Spectrometry,Journal of Proteome Research,2014年04月,Vol.13, No.4,2056-2068
Studying Neurodegenerative Diseases in Culture Models,Revista Brasileira de Psiquiatria,2013年01月,Vol.35,S92-S100
Studying Neurodegenerative Diseases in Culture Models,Revista Brasileira de Psiquiatria,2013年01月,Vol.35,S92-S100
Attorney, Agent or Firm:
Toru Ishikawa