Title:
MATRIX METALLOPROTEINASE-INHIBITING 2-OXO-IMIDAZOLIDINE-4- CARBOXYLIC ACID HYDROXAMIDE COMPOUND
Document Type and Number:
Japanese Patent JP3841646
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a 2-oxo-imidazolidine-4-carboxylic acid hydroxisamde derivative, a medicinal composition containing the same derivative and a use of the above derivative in the treatment of arthritis, inflammation, cancer and the other diseases.
SOLUTION: This 2-oxo-imidazolidine-4-carboxylic acid hydroxisamde compound is a compound of the formula, wherein, R1 to R4 are each designated in the specification, its pharmaceutically permissible salts and solvated materials, and useful as a matrix metalloproteinase inhibitor. The pharmaceutical composition containing such compound and a method for treating diseases characterized by an inappropriate matrix metalloproteinase activity such as osteo arthritis, chronic rheumatoide arthritis, cancer, osteoporosis, tissue tumorigenesis, restenosis, periodontal disease, inflammation, bolus dermatosis, pleurisy, cerebral stroke, Alzheimer disease, etc., are provided. The method for synthesizing the compound expressed by the formula (1) is also provided.
Inventors:
Ellen Ruth Liard
Ralph Pelton Robinson Jr.
Ralph Pelton Robinson Jr.
Application Number:
JP2001043556A
Publication Date:
November 01, 2006
Filing Date:
February 20, 2001
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D233/32; A61K31/4166; A61K31/4174; A61P1/00; A61P1/02; A61P1/04; A61P3/10; A61P7/00; A61P9/04; A61P9/10; A61P9/14; A61P11/00; A61P17/00; A61P17/02; A61P19/02; A61P19/10; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D401/06; C07D401/12; C07D491/10; (IPC1-7): C07D233/32; A61K31/4166; A61K31/4174; A61P1/00; A61P1/02; A61P1/04; A61P3/10; A61P7/00; A61P9/04; A61P9/10; A61P9/14; A61P11/00; A61P17/00; A61P17/02; A61P19/02; A61P19/10; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P37/02; A61P37/08; A61P43/00
Foreign References:
| WO1999065867A1 |
Attorney, Agent or Firm:
Yoshinobu Murofushi
Masahiro Nanjo
Junko Miyazawa
Masahiro Nanjo
Junko Miyazawa
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